Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)

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PH2; GLXR; Primary Hyperoxaluria Type 2

Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)
GRHPR encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
The GRHPR gene encodes a predicted 328-amino acid protein with a calculated molecular mass of 35.5 kD. By transient transfection of the cDNA clone into COS cells, Cramer et al. (1999) verified that GRHPR encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. Database analysis of human ESTs revealed widespread tissue expression, indicating that the enzyme may have a role in metabolism.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)CLIA Kit Customized Service Offer
n/aELISA Kit for Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)CLIA Kit Customized Service Offer
n/aELISA Kit for Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)CLIA Kit Customized Service Offer
n/aELISA Kit for Glyoxylate Reductase/Hydroxypyruvate Reductase (GRHPR)ELISA Kit Customized Service Offer
  1. "Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase."Biochim. Biophys. Acta 1446:383-388(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II."Hum. Mol. Genet. 8:2063-2069(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and characterization of a putative human D-2-hydroxyacid dehydrogenase in chromosome 9q."Biochem. Biophys. Res. Commun. 268:298-301(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase."J. Mol. Biol. 360:178-189(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of a glyoxylate/hydroxypyruvate reductase from Homo sapiens."Submitted (FEB-2009) to the PDB data bank