Alkaline Ceramidase 3 (ACER3)

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APHC; PHCA; Alkaline Phytoceramidase; Alkaline dihydroceramidase SB89

Alkaline Ceramidase 3 (ACER3)
ACER3 is a ceramidase enzyme encoded by the ACER3 gene.In cells, ACER3 overexpression decreased C18:1- and C20:1-ceramides and dihydroceramides, whereas ACER3 knockdown by RNA interference had the opposite effect, suggesting that ACER3 controls the catabolism of ULC ceramides and dihydroceramides. ACER3 knockdown inhibited cell apoptosis in response to serum deprivation. ACER3 knockdown up-regulated the expression of the alkaline ceramidase 2 (ACER2), and the ACER2 up-regulation decreased non-ULC ceramide species while increasing both sphingosine and its phosphate. Collectively, these data suggest that ACER3 catalyzes the hydrolysis of ULC ceramides and dihydroceramides and that ACER3 coordinates with ACER2 to regulate cell proliferation and survival.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Alkaline Ceramidase 3 (ACER3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Alkaline Ceramidase 3 (ACER3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Alkaline Ceramidase 3 (ACER3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Alkaline Ceramidase 3 (ACER3)CLIA Kit Customized Service Offer
n/aELISA Kit for Alkaline Ceramidase 3 (ACER3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Alkaline Ceramidase 3 (ACER3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Alkaline Ceramidase 3 (ACER3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Alkaline Ceramidase 3 (ACER3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Alkaline Ceramidase 3 (ACER3)CLIA Kit Customized Service Offer
n/aELISA Kit for Alkaline Ceramidase 3 (ACER3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Alkaline Ceramidase 3 (ACER3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Alkaline Ceramidase 3 (ACER3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Alkaline Ceramidase 3 (ACER3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Alkaline Ceramidase 3 (ACER3)CLIA Kit Customized Service Offer
n/aELISA Kit for Alkaline Ceramidase 3 (ACER3)ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide."J. Biol. Chem. 276:26577-26588(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]