G Protein Coupled Receptor 56 (GPR56)

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BFPP; TM7LN4; TM7XN1; GPR56 seven-transmembrane subunit

G Protein Coupled Receptor 56 (GPR56)
GPR56 encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis.
The predicted 693-amino acid GPR56 protein shares 26 to 32% sequence identity with the 4 class B-like orphan receptors. Like these receptors, GPR56 contains 7 transmembrane domains as well as a mucin-like domain and cysteine box in the N-terminal region.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant G Protein Coupled Receptor 56 (GPR56)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to G Protein Coupled Receptor 56 (GPR56)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to G Protein Coupled Receptor 56 (GPR56)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for G Protein Coupled Receptor 56 (GPR56)CLIA Kit Customized Service Offer
n/aELISA Kit for G Protein Coupled Receptor 56 (GPR56)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant G Protein Coupled Receptor 56 (GPR56)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to G Protein Coupled Receptor 56 (GPR56)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to G Protein Coupled Receptor 56 (GPR56)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for G Protein Coupled Receptor 56 (GPR56)CLIA Kit Customized Service Offer
n/aELISA Kit for G Protein Coupled Receptor 56 (GPR56)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant G Protein Coupled Receptor 56 (GPR56)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to G Protein Coupled Receptor 56 (GPR56)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to G Protein Coupled Receptor 56 (GPR56)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for G Protein Coupled Receptor 56 (GPR56)CLIA Kit Customized Service Offer
n/aELISA Kit for G Protein Coupled Receptor 56 (GPR56)ELISA Kit Customized Service Offer
  1. "GPR56, a novel secretin-like human G-protein-coupled receptor gene."Genomics 55:296-305(1999) [PubMed] [Europe PMC] [Abstract]
  2. "TM7XN1, a novel human EGF-TM7 like protein, detected with mRNA differential display using human melanoma cell lines with different metastatic potential."FEBS Lett. 446:292-298(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
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  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association."Mol. Biol. Cell 15:2375-2387(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis."Proc. Natl. Acad. Sci. U.S.A. 103:9023-9028(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis."J. Cancer Res. Clin. Oncol. 136:47-53(2010) [PubMed] [Europe PMC] [Abstract]
  13. "GPR56 Regulates VEGF production and angiogenesis during melanoma progression."Cancer Res. 71:5558-5568(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms."J. Biol. Chem. 286:14215-14225(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity."J. Biol. Chem. 286:28914-28921(2011) [PubMed] [Europe PMC] [Abstract]
  16. "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis."EMBO J. 31:1364-1378(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Disease-associated mutations prevent GPR56-collagen III interaction."PLoS ONE 7:E29818-E29818(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning."Science 343:764-768(2014) [PubMed] [Europe PMC] [Abstract]
  19. "G protein-coupled receptor-dependent development of human frontal cortex."Science 303:2033-2036(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes."Ann. Neurol. 58:680-687(2005) [PubMed] [Europe PMC] [Abstract]
  21. "A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria."Pediatr. Neurol. 45:49-53(2011) [PubMed] [Europe PMC] [Abstract]