WNK Lysine Deficient Protein Kinase 4 (WNK4)

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PHA2B; PRKWNK4; Protein Kinase,Lysine Deficient 4; Protein kinase with no lysine 4; Serine/threonine-protein kinase WNK4

WNK Lysine Deficient Protein Kinase 4 (WNK4)
WNK4 encodes a serine-threonine kinase expressed in distal nephron. Its primary role in renal physiolgy is as a molecular switch between the angiontensin II - aldosterone mediated volume retention and the aldosterone mediated potassium wasting. This is achieved by regulating the sodium-chloride symporter (NCC), that is uniquely expressed in the distal nephron and is sensitive to thiazide type diuretics. WNK4 will inhibit NCC function. It has been proposed that in the event of hyperkalemia and an increased secretion of aldosterone, this inhibition of NCC, will allow an increase in the arrival of sodium to the distal nephron which will allow the exchange of sodium for potassium ions, thereby reducing plasma potassium levels, without increasing sodium chloride retention.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant WNK Lysine Deficient Protein Kinase 4 (WNK4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)CLIA Kit Customized Service Offer
n/aELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant WNK Lysine Deficient Protein Kinase 4 (WNK4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)CLIA Kit Customized Service Offer
n/aELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant WNK Lysine Deficient Protein Kinase 4 (WNK4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)CLIA Kit Customized Service Offer
n/aELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)ELISA Kit Customized Service Offer
  1. "Human hypertension caused by mutations in WNK kinases."Science 293:1107-1112(2001) [PubMed] [Europe PMC] [Abstract].
  2. Thesis (2001), College de France / Paris, France.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms."Oncogene 20:5562-5569(2001) [PubMed] [Europe PMC] [Abstract].
  6. "Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members."J. Biol. Chem. 285:25161-25167(2010) [PubMed] [Europe PMC] [Abstract]
  7. "KLHL2 interacts with and ubiquitinates WNK kinases."Biochem. Biophys. Res. Commun. 437:457-462(2013) [PubMed] [Europe PMC] [Abstract]
  8. "The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction."Biochem. J. 451:111-122(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension."Cell Rep. 3:858-868(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation."FEBS Lett. 587:1717-1722(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4."Proc. Natl. Acad. Sci. U.S.A. 110:7838-7843(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]