UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)

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UGT1; GNT1; UGT1A; UDPGT; HUG-BR1; UGT1-1; Bilirubin-specific UDPGT isozyme 1; UDP-glucuronosyltransferase 1-1

UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)
UGT-1A is a uridine diphosphate glucuronyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The UGT1A1 gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPG920Hu01Recombinant UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAG920Hu21Monoclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)WB, ICC, IHC-P, IHC-F, ELISA
PAG920Hu01Polyclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEG920HuELISA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)CLIA Kit Customized Service Offer
n/aELISA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPG920Ra01Recombinant UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAG920Ra21Monoclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)WB, ICC, IHC-P, IHC-F, ELISA
PAG920Ra01Polyclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEG920RaELISA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1)Enzyme-linked immunosorbent assay for Antigen Detection
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  19. "A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase."J. Biol. Chem. 268:23573-23579(1993) [PubMed] [Europe PMC] [Abstract]
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  22. "Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase."J. Clin. Invest. 94:2385-2391(1994) [PubMed] [Europe PMC] [Abstract]
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  25. "Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease."Biochim. Biophys. Acta 1407:40-50(1998) [PubMed] [Europe PMC] [Abstract]
  26. "Analysis of bilirubin uridine 5'-diphosphate (UDP)-glucuronosyltransferase gene mutations in seven patients with Crigler-Najjar syndrome type II."J. Hum. Genet. 43:111-114(1998) [PubMed] [Europe PMC] [Abstract]
  27. "Gilbert syndrome caused by a homozygous missense mutation (Tyr486Asp) of bilirubin UDP-glucuronosyltransferase gene."J. Pediatr. 132:1045-1047(1998) [PubMed] [Europe PMC] [Abstract]
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  29. "Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene."Pediatrics 106:E59-E59(2000) [PubMed] [Europe PMC] [Abstract]
  30. "Interaction of coding region mutations and the Gilbert-type promoter abnormality of the UGT1A1 gene causes moderate degrees of unconjugated hyperbilirubinaemia and may lead to neonatal kernicterus."J. Med. Genet. 38:244-249(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Association of a homozygous (TA)8 promoter polymorphism and a N400D mutation of UGT1A1 in a child with Crigler-Najjar type II syndrome."Hum. Mutat. 20:399-401(2002) [PubMed] [Europe PMC] [Abstract]
  32. "Novel missense mutation of the UGT1A1 gene in Thai siblings with Gilbert's syndrome."Pediatr. Int. 44:427-432(2002) [PubMed] [Europe PMC] [Abstract]
  33. "Rapid proteasomal degradation of translocation-deficient UDP-glucuronosyltransferase 1A1 proteins in patients with Crigler-Najjar type II."Biochem. Biophys. Res. Commun. 310:735-741(2003) [PubMed] [Europe PMC] [Abstract]
  34. "Spectrum of UGT1A1 mutations in Crigler-Najjar (CN) syndrome patients: identification of twelve novel alleles and genotype-phenotype correlation."Hum. Mutat. 25:325-325(2005) [PubMed] [Europe PMC] [Abstract]
  35. "Seven novel mutations of the UGT1A1 gene in patients with unconjugated hyperbilirubinemia."Haematologica 92:133-134(2007) [PubMed] [Europe PMC] [Abstract]
  36. "UGT1A1 gene mutations in Pakistani children suffering from inherited nonhemolytic unconjugated hyperbilirubinemias."Ann. Hum. Genet. 77:482-487(2013) [PubMed] [Europe PMC] [Abstract]
  37. "Identification of a novel mutation in UDP-glucuronosyltransferase (UGT1A1) gene in a child with neonatal unconjugated hyperbilirubinemia."Clin. Biochem. 46:170-172(2013) [PubMed] [Europe PMC] [Abstract]