UDP Glucuronosyltransferase 1 Family, Polypeptide A7 (UGT1A7)

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UGT1G; GNT1; UGT1; UDP-glucuronosyltransferase 1-G

UDP Glucuronosyltransferase 1 Family, Polypeptide A7 (UGT1A7)
Enzymes of the UDP glycosyltransferase (UGT; EC 2.4.1.17) superfamily covalently link glycosyl groups to lipophilic substrates. UGT1A enzymes, such as UGT1A7, efficiently use UDP-glucuronic acid as the glycosyl donor and are invaluable in detoxifying both endogenous and foreign chemicals, because the glycosylated chemical is more water soluble and therefore more readily excreted.
Several UGT1A enzymes, including UGT1A7, are encoded by the UGT1A gene complex on chromosome 2q37. Within this complex, 9 viable first exons are independently spliced to 4 common exons to generate 9 UGT1A transcripts with unique 5-prime ends and identical 3-prime ends. UGT1A7, like each first exon within the UGT1A gene complex, is considered a unique gene linked to the 4 common exons.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant UDP Glucuronosyltransferase 1 Family, Polypeptide A7 (UGT1A7)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A7 (UGT1A7)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to UDP Glucuronosyltransferase 1 Family, Polypeptide A7 (UGT1A7)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A7 (UGT1A7)CLIA Kit Customized Service Offer
n/aELISA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A7 (UGT1A7)ELISA Kit Customized Service Offer
  1. "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue."Mol. Pharmacol. 52:212-220(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."Pharmacogenetics 11:357-368(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."Pharmacogenet. Genomics 17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro."Drug Metab. Dispos. 38:1785-1789(2010) [PubMed] [Europe PMC] [Abstract]
  6. "The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro."Drug Metab. Dispos. 41:694-697(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene."Pharmacogenetics 10:629-644(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population."Hum. Mutat. 30:677-687(2009) [PubMed] [Europe PMC] [Abstract]