Serine/Threonine Kinase 11 (STK11)

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LKB1; PJS; Polarization-Related Protein LKB1; Peutz-Jeghers Syndrome; Liver kinase B1; Renal carcinoma antigen NY-REN-19

Serine/Threonine Kinase 11 (STK11)
LKB1 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It is now clear that LKB1 exerts its growth suppressing effects by activating a group of other ~14 kinases, comprising AMPK and AMPK-related kinases. Activation of AMPK by LKB1 suppresses growth and proliferation when energy and nutrient levels are scarce. Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate expansion of tumour cells. A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour growth under energetically unfavorable conditions.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Serine/Threonine Kinase 11 (STK11)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Serine/Threonine Kinase 11 (STK11)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Serine/Threonine Kinase 11 (STK11)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Serine/Threonine Kinase 11 (STK11)CLIA Kit Customized Service Offer
n/aELISA Kit for Serine/Threonine Kinase 11 (STK11)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH115Mu01Recombinant Serine/Threonine Kinase 11 (STK11)SDS-PAGE; WB; ELISA; IP.
RPH115Mu02Recombinant Serine/Threonine Kinase 11 (STK11)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAH115Mu01Polyclonal Antibody to Serine/Threonine Kinase 11 (STK11)WB, ICC, IHC-P, IHC-F, ELISA
PAH115Mu02Polyclonal Antibody to Serine/Threonine Kinase 11 (STK11)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEH115MuELISA Kit for Serine/Threonine Kinase 11 (STK11)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Serine/Threonine Kinase 11 (STK11)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Serine/Threonine Kinase 11 (STK11)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Serine/Threonine Kinase 11 (STK11)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Serine/Threonine Kinase 11 (STK11)CLIA Kit Customized Service Offer
n/aELISA Kit for Serine/Threonine Kinase 11 (STK11)ELISA Kit Customized Service Offer
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  2. "Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer."Cancer Res. 58:1384-1386(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Frequent loss of heterozygosity at the 19p13.3 locus without LKB1/STK11 mutations in human carcinoma metastases to the brain."J. Neurooncol. 49:187-195(2000) [PubMed] [Europe PMC] [Abstract]
  8. "LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1."Hum. Mol. Genet. 10:2869-2877(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death."Mol. Cell 7:1307-1319(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung."Cancer Res. 62:3659-3662(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD."EMBO J. 22:3062-3072(2003) [PubMed] [Europe PMC] [Abstract]
  12. "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm."EMBO J. 22:5102-5114(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD."Cell 116:457-466(2004) [PubMed] [Europe PMC] [Abstract]
  14. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene."Oncogene 23:4037-4040(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate."FEBS Lett. 579:1417-1423(2005) [PubMed] [Europe PMC] [Abstract]
  17. "LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes."Hum. Mol. Genet. 14:2209-2219(2005) [PubMed] [Europe PMC] [Abstract]
  18. "LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation."Cancer Res. 66:10701-10708(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction."Mol. Cell. Biochem. 301:115-122(2007) [PubMed] [Europe PMC] [Abstract]
  20. "LKB1 gene mutations in Japanese lung cancer patients."Cancer Sci. 98:1747-1751(2007) [PubMed] [Europe PMC] [Abstract]
  21. "LKB1 modulates lung cancer differentiation and metastasis." Nature 448:807-810(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Prevalence and specificity of LKB1 genetic alterations in lung cancers."Oncogene 26:5911-5918(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients."Br. J. Cancer 99:245-252(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells."J. Biol. Chem. 283:12446-12455(2008) [PubMed] [Europe PMC] [Abstract]
  25. "SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation."J. Biol. Chem. 283:27628-27635(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Characterization of an alternative splice variant of LKB1."J. Biol. Chem. 284:67-76(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Spectrum of LKB1, EGFR, and KRAS mutations in Chinese lung adenocarcinomas."J. Thorac. Oncol. 5:1130-1135(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  30. "A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation."Oncogene 30:2933-2942(2011) [PubMed] [Europe PMC] [Abstract]
  31. "The role of LKB1 and AMPK in cellular responses to stress and damage."FEBS Lett. 585:952-957(2011) [PubMed] [Europe PMC] [Abstract]
  32. "LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor."Protein Cell 2:99-107(2011) [PubMed] [Europe PMC] [Abstract]
  33. "The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK." Nat. Chem. Biol. 8:897-904(2012) [PubMed] [Europe PMC] [Abstract]
  34. "Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells."J. Biol. Chem. 288:15495-15509(2013) [PubMed] [Europe PMC] [Abstract]
  35. "Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Czeta is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation."J. Biol. Chem. 288:16495-16505(2013) [PubMed] [Europe PMC] [Abstract]
  36. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  37. "A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation."PLoS Genet. 10:E1004721-E1004721(2014) [PubMed] [Europe PMC] [Abstract]
  38. "Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation."Science 326:1707-1711(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity."Am. J. Hum. Genet. 63:1641-1650(1998) [PubMed] [Europe PMC] [Abstract]
  40. "Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors."Cancer Res. 58:2087-2090(1998) [PubMed] [Europe PMC] [Abstract]
  41. "Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer."Cancer Res. 58:3787-3790(1998) [PubMed] [Europe PMC] [Abstract]
  42. "STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer."Cancer Res. 58:4799-4801(1998) [PubMed] [Europe PMC] [Abstract]
  43. "Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome."Hum. Genet. 103:168-172(1998) [PubMed] [Europe PMC] [Abstract]
  44. "Mutations of the STK11 gene in sporadic gastric carcinoma."Int. J. Oncol. 13:601-604(1998) [PubMed] [Europe PMC] [Abstract]
  45. "A serine/threonine kinase gene defective in Peutz-Jeghers syndrome." Nature 391:184-187(1998) [PubMed] [Europe PMC] [Abstract]
  46. "LKB1 somatic mutations in sporadic cancers."Am. J. Pathol. 154:677-681(1999) [PubMed] [Europe PMC] [Abstract]
  47. "Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families."Hum. Mutat. 13:476-481(1999) [PubMed] [Europe PMC] [Abstract]
  48. "Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer."Hum. Mol. Genet. 8:45-51(1999) [PubMed] [Europe PMC] [Abstract]
  49. "Mutational analysis of STK11 gene in ovarian carcinomas."Jpn. J. Cancer Res. 90:629-632(1999) [PubMed] [Europe PMC] [Abstract]
  50. "Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas."J. Invest. Dermatol. 112:509-511(1999) [PubMed] [Europe PMC] [Abstract]
  51. "Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma."Oncogene 18:1777-1780(1999) [PubMed] [Europe PMC] [Abstract]
  52. "Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients."Clin. Genet. 62:282-287(2002) [PubMed] [Europe PMC] [Abstract]
  53. "Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix."Lab. Invest. 83:35-45(2003) [PubMed] [Europe PMC] [Abstract]
  54. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  55. "A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity."Clin. Res. Hepatol. Gastroenterol. 35:221-226(2011) [PubMed] [Europe PMC] [Abstract]