SET Binding Protein 1 (SETBP1)
The transcript contains 2 polyadenylation signals, and the deduced protein contains 1,542 amino acids and has a calculated molecular mass of 170 kD. SETBP1 contains a central SKI homology region and a C-terminal SET-binding domain that is followed by 3 sequential PPLPPPPP repeats. SETBP1 also has 3 bipartite nuclear localization signals, 6 PEST sequences, 4 KxKHKxK repeats, 8 LSxxL repeats, and 10 PxxPS repeats. Northern blot analysis detected a major 5.8-kb transcript in all tissues and cell lines examined. Immunofluorescence analysis detected fluorescence-tagged and endogenous SETBP1 predominantly in nuclei of human cell lines.Immunoprecipitation analysis verified that SETBP1 interacted with endogenous SET in a human osteosarcoma cell line.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SET Binding Protein 1 (SETBP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SET Binding Protein 1 (SETBP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SET Binding Protein 1 (SETBP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SET Binding Protein 1 (SETBP1)CLIA Kit Customized Service Offer
n/aELISA Kit for SET Binding Protein 1 (SETBP1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SET Binding Protein 1 (SETBP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SET Binding Protein 1 (SETBP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SET Binding Protein 1 (SETBP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SET Binding Protein 1 (SETBP1)CLIA Kit Customized Service Offer
n/aELISA Kit for SET Binding Protein 1 (SETBP1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant SET Binding Protein 1 (SETBP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to SET Binding Protein 1 (SETBP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to SET Binding Protein 1 (SETBP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for SET Binding Protein 1 (SETBP1)CLIA Kit Customized Service Offer
n/aELISA Kit for SET Binding Protein 1 (SETBP1)ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET."Eur. J. Biochem. 268:1340-1351(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Refining analyses of copy number variation identifies specific genes associated with developmental delay." Nat. Genet. 46:1063-1071(2014) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  9. "De novo mutations of SETBP1 cause Schinzel-Giedion syndrome." Nat. Genet. 42:483-485(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression."Br. J. Haematol. 163:235-239(2013) [PubMed] [Europe PMC] [Abstract]
  11. "SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations."Leukemia 27:1852-1860(2013) [PubMed] [Europe PMC] [Abstract]
  12. "SETBP1 mutation analysis in 944 patients with MDS and AML. Hannover, Germany."Leukemia 27:2072-2075(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Recurrent SETBP1 mutations in atypical chronic myeloid leukemia." Nat. Genet. 45:18-24(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia." Nat. Genet. 45:937-941(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Somatic SETBP1 mutations in myeloid malignancies." Nat. Genet. 45:942-946(2013) [PubMed] [Europe PMC] [Abstract]