SET Binding Protein 1 (SETBP1)
The transcript contains 2 polyadenylation signals, and the deduced protein contains 1,542 amino acids and has a calculated molecular mass of 170 kD. SETBP1 contains a central SKI homology region and a C-terminal SET-binding domain that is followed by 3 sequential PPLPPPPP repeats. SETBP1 also has 3 bipartite nuclear localization signals, 6 PEST sequences, 4 KxKHKxK repeats, 8 LSxxL repeats, and 10 PxxPS repeats. Northern blot analysis detected a major 5.8-kb transcript in all tissues and cell lines examined. Immunofluorescence analysis detected fluorescence-tagged and endogenous SETBP1 predominantly in nuclei of human cell lines.Immunoprecipitation analysis verified that SETBP1 interacted with endogenous SET in a human osteosarcoma cell line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH180Hu01 Recombinant SET Binding Protein 1 (SETBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to SET Binding Protein 1 (SETBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Binding Protein 1 (SETBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Binding Protein 1 (SETBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Binding Protein 1 (SETBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Binding Protein 1 (SETBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Binding Protein 1 (SETBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Binding Protein 1 (SETBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Binding Protein 1 (SETBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Binding Protein 1 (SETBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Binding Protein 1 (SETBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Binding Protein 1 (SETBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Binding Protein 1 (SETBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Binding Protein 1 (SETBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Binding Protein 1 (SETBP1) ELISA Kit Customized Service Offer
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  9. "De novo mutations of SETBP1 cause Schinzel-Giedion syndrome." Nat. Genet. 42:483-485(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression."Br. J. Haematol. 163:235-239(2013) [PubMed] [Europe PMC] [Abstract]
  11. "SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations."Leukemia 27:1852-1860(2013) [PubMed] [Europe PMC] [Abstract]
  12. "SETBP1 mutation analysis in 944 patients with MDS and AML. Hannover, Germany."Leukemia 27:2072-2075(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Recurrent SETBP1 mutations in atypical chronic myeloid leukemia." Nat. Genet. 45:18-24(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia." Nat. Genet. 45:937-941(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Somatic SETBP1 mutations in myeloid malignancies." Nat. Genet. 45:942-946(2013) [PubMed] [Europe PMC] [Abstract]