Protein Kinase, X-Linked (PRKX)

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PKX1; cAMP-dependent protein kinase catalytic subunit PRKX

Protein Kinase, X-Linked (PRKX)
PKX1 appeared to encode a novel type of protein kinase that is related to the catalytic subunit of cAMP-dependent protein kinases and has striking homology to the DC2 protein kinase of Drosophila melanogaster. PKX1 is part of a family of at least 4 genes or pseudogenes, of which 3 map to the human sex chromosomes. In contrast to all other genes from the X-specific region of Xp22.3, PKX1 has a homolog on Yp (PRKY) rather than Yq. This suggests that the single pericentric inversion event hypothesized to have occurred during primate evolution is not sufficient to explain the present X/Y homology pattern of Xp22.3.This suggests that the PKX1 gene, besides harboring a previously described hotspot for illegitimate Xp/Yp recombination, contains additional sequences which predispose the X chromosome to breakage events.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Protein Kinase, X-Linked (PRKX)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Protein Kinase, X-Linked (PRKX)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Protein Kinase, X-Linked (PRKX)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Protein Kinase, X-Linked (PRKX)CLIA Kit Customized Service Offer
n/aELISA Kit for Protein Kinase, X-Linked (PRKX)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Protein Kinase, X-Linked (PRKX)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Protein Kinase, X-Linked (PRKX)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Protein Kinase, X-Linked (PRKX)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Protein Kinase, X-Linked (PRKX)CLIA Kit Customized Service Offer
n/aELISA Kit for Protein Kinase, X-Linked (PRKX)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH312Ra01Recombinant Protein Kinase, X-Linked (PRKX)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAH312Ra21Monoclonal Antibody to Protein Kinase, X-Linked (PRKX)WB, ICC, IHC-P, IHC-F, ELISA
PAH312Ra01Polyclonal Antibody to Protein Kinase, X-Linked (PRKX)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEH312RaELISA Kit for Protein Kinase, X-Linked (PRKX)Enzyme-linked immunosorbent assay
  1. "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability."Hum. Mol. Genet. 4:869-878(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females."Hum. Mol. Genet. 6:1985-1989(1997) [PubMed] [Europe PMC] [Abstract]
  4. "A lineage-specific protein kinase crucial for myeloid maturation."Proc. Natl. Acad. Sci. U.S.A. 95:15412-15417(1998) [PubMed] [Europe PMC] [Abstract]
  5. "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I."J. Biol. Chem. 274:5370-5378(1999) [PubMed] [Europe PMC] [Abstract]
  6. "PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis."Proc. Natl. Acad. Sci. U.S.A. 99:9260-9265(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney."J. Am. Soc. Nephrol. 16:3543-3552(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Profiles of PrKX expression in developmental mouse embryo and human tissues."J. Histochem. Cytochem. 53:1003-1009(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency."Biochim. Biophys. Acta 1782:1-9(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development."Kidney Int. 76:54-62(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop."J. Biol. Chem. 285:35910-35918(2010) [PubMed] [Europe PMC] [Abstract]
  13. "PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation."Dev. Biol. 356:475-485(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]