Prolactin Regulatory Element Binding Protein (PREB)

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SEC12; Mammalian guanine nucleotide exchange factor mSec12

Prolactin Regulatory Element Binding Protein (PREB)
PREB may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.The deduced 417-amino acid protein, which is 89% identical to the rat protein, has 3 conserved WD repeats and 2 conserved pro-gln-rich regions. RNA dot blot analysis detected variable expression of PREB in all adult and fetal tissues. They proposed that PREB is a DNA-binding factor during mammalian development and that abnormal dosage may play a role in some of the phenotypic abnormalities observed in the partial trisomy 2p syndrome, which is characterized by a number of congenital defects, including genital abnormalities.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prolactin Regulatory Element Binding Protein (PREB)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prolactin Regulatory Element Binding Protein (PREB)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prolactin Regulatory Element Binding Protein (PREB)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prolactin Regulatory Element Binding Protein (PREB)CLIA Kit Customized Service Offer
n/aELISA Kit for Prolactin Regulatory Element Binding Protein (PREB)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prolactin Regulatory Element Binding Protein (PREB)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prolactin Regulatory Element Binding Protein (PREB)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prolactin Regulatory Element Binding Protein (PREB)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prolactin Regulatory Element Binding Protein (PREB)CLIA Kit Customized Service Offer
n/aELISA Kit for Prolactin Regulatory Element Binding Protein (PREB)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Prolactin Regulatory Element Binding Protein (PREB)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prolactin Regulatory Element Binding Protein (PREB)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prolactin Regulatory Element Binding Protein (PREB)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prolactin Regulatory Element Binding Protein (PREB)CLIA Kit Customized Service Offer
n/aELISA Kit for Prolactin Regulatory Element Binding Protein (PREB)ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome."Mamm. Genome 11:675-681(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12."BMC Genomics 4:18-18(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]