Polyglutamine Binding Protein 1 (PQBP1)

[Edit]

Npw38; RENS1; MRXS8; SHS; MRX55; Sutherland-Haan X-Linked Mental Retardation Syndrome; Mental Retardation,X-Linked 55; 38 kDa nuclear protein containing a WW domain

Polyglutamine Binding Protein 1 (PQBP1)
PQBP1 encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
The deduced 265-amino acid PQBP1 protein contains an N-terminal WW domain, a protein-protein interaction motif that has 2 conserved trp (W) residues, which lies between an acidic region and an acidic-basic amino acid repetitive region. PQBP1 also has a putative nuclear localization signal.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polyglutamine Binding Protein 1 (PQBP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polyglutamine Binding Protein 1 (PQBP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polyglutamine Binding Protein 1 (PQBP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polyglutamine Binding Protein 1 (PQBP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Polyglutamine Binding Protein 1 (PQBP1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polyglutamine Binding Protein 1 (PQBP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polyglutamine Binding Protein 1 (PQBP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polyglutamine Binding Protein 1 (PQBP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polyglutamine Binding Protein 1 (PQBP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Polyglutamine Binding Protein 1 (PQBP1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polyglutamine Binding Protein 1 (PQBP1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polyglutamine Binding Protein 1 (PQBP1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polyglutamine Binding Protein 1 (PQBP1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polyglutamine Binding Protein 1 (PQBP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Polyglutamine Binding Protein 1 (PQBP1)ELISA Kit Customized Service Offer
  1. "PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival."Hum. Mol. Genet. 8:977-987(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Npw38, a novel nuclear protein possessing a WW domain capable of activating basal transcription."Nucleic Acids Res. 27:1957-1965(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization and alternative transcripts of the human PQBP-1 gene."Gene 259:69-73(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]