Pyruvate Dehydrogenase Complex Component X (PDHX)

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E3BP; proX; PDX1; OPDX; DLDBP; E3-binding protein; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex

Pyruvate Dehydrogenase Complex Component X (PDHX)
The PDHX gene encodes component X of the pyruvate dehydrogenase (PDH) complex. For a detailed description of the pyruvate dehydrogenase complex. The mammalian PDH complex differs from that in E. coli and from the other mammalian alpha-keto acid dehydrogenases by the presence of a 53-kD protein called protein X. Component X binds to the E3 component of the PDH complex.
The open reading frame encodes an 501-amino acid protein sequence that is 20% identical with that encoded by the yeast PDX1 gene and 40% identical with that encoded by the lipoacyltransferase component E2 of the PDH (E2), and includes a lipoyl-bearing domain. Sequence comparisons showed that the PDHX protein contains an E3-binding domain.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH426Hu01Recombinant Pyruvate Dehydrogenase Complex Component X (PDHX)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAH426Hu01Polyclonal Antibody to Pyruvate Dehydrogenase Complex Component X (PDHX)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Pyruvate Dehydrogenase Complex Component X (PDHX)CLIA Kit Customized Service Offer
n/aELISA Kit for Pyruvate Dehydrogenase Complex Component X (PDHX)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH426Mu01Recombinant Pyruvate Dehydrogenase Complex Component X (PDHX)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAH426Mu01Polyclonal Antibody to Pyruvate Dehydrogenase Complex Component X (PDHX)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Pyruvate Dehydrogenase Complex Component X (PDHX)CLIA Kit Customized Service Offer
n/aELISA Kit for Pyruvate Dehydrogenase Complex Component X (PDHX)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Pyruvate Dehydrogenase Complex Component X (PDHX)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Pyruvate Dehydrogenase Complex Component X (PDHX)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Pyruvate Dehydrogenase Complex Component X (PDHX)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Pyruvate Dehydrogenase Complex Component X (PDHX)CLIA Kit Customized Service Offer
n/aELISA Kit for Pyruvate Dehydrogenase Complex Component X (PDHX)ELISA Kit Customized Service Offer
  1. "Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex."J. Biol. Chem. 272:19746-19751(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis."Am. J. Hum. Genet. 61:1318-1326(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Detection of a homozygous four base pair deletion in the protein X gene in a case of pyruvate dehydrogenase complex deficiency."Hum. Mol. Genet. 7:501-505(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Large-scale concatenation cDNA sequencing."Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components."J. Biol. Chem. 279:6921-6933(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
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  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex."J. Biol. Chem. 281:648-655(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex."Structure 14:611-621(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase."Submitted (OCT-2006) to the PDB data bank