V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)

[Edit]

c-MAF; Proto-oncogene c-Maf; Transcription factor Maf

V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)
MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor.
This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.Members of the MAF family appear to play important roles in the regulation of differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPH596Hu01Recombinant V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)SDS-PAGE; WB; ELISA; IP.
AntibodiesMAH596Hu21Monoclonal Antibody to V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)WB, ICC, IHC-P, IHC-F, ELISA
PAH596Hu01Polyclonal Antibody to V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEH596HuELISA Kit for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)CLIA Kit Customized Service Offer
n/aELISA Kit for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)CLIA Kit Customized Service Offer
n/aELISA Kit for V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)ELISA Kit Customized Service Offer
  1. "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma."Blood 91:4457-4463(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction."Oncogene 21:5301-5312(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma."Cancer Cell 5:191-199(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer."Oncogene 23:3487-3494(2004) [PubMed] [Europe PMC] [Abstract]
  7. "MafA transcription factor is phosphorylated by p38 MAP kinase."FEBS Lett. 579:3547-3554(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin."Blood 110:4047-4054(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Cell context reveals a dual role for Maf in oncogenesis."Oncogene 25:1299-1310(2006) [PubMed] [Europe PMC] [Abstract]
  10. "CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element."Gene 403:178-187(2007) [PubMed] [Europe PMC] [Abstract]
  11. "GSK-3-mediated phosphorylation enhances Maf-transforming activity."Mol. Cell 28:584-597(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A new MAFia in cancer."Nat. Rev. Cancer 8:683-693(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma."Hum. Mol. Genet. 11:33-42(2002) [PubMed] [Europe PMC] [Abstract]
  14. "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant 'cerulean cataract' in an Indian family."Am. J. Med. Genet. A 140:558-566(2006) [PubMed] [Europe PMC] [Abstract]