Leucine Rich Repeat Kinase 1 (LRRK1)

[Edit]

RIPK6; Roco1; Leucine-rich repeat serine/threonine-protein kinase 1

Leucine Rich Repeat Kinase 1 (LRRK1)
LRRK1has a domain organization similar to that of LRRK2, with 6 N-terminal ankyrin repeats, followed by 14 leucine-rich repeats, a RAS (see HRAS)-like GTPase domain (ROC domain), a C-terminal to ROC (COR) domain, a serine/threonine kinase domain, and 7 C-terminal WD40 repeats. Highest expression of LRRK1 was in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. LRRK1 underwent intramolecular, but not intermolecular, autophosphorylation. Replacement of lys1269 with trp in the ATP-binding niche of the kinase domain of LRRK1 significantly reduced autophosphorylation activity. LRRK1 also functioned as a GDP/GTP-binding protein, and its kinase activity was stimulated upon binding of GTP to the ROC domain.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Leucine Rich Repeat Kinase 1 (LRRK1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Leucine Rich Repeat Kinase 1 (LRRK1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Leucine Rich Repeat Kinase 1 (LRRK1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Leucine Rich Repeat Kinase 1 (LRRK1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Leucine Rich Repeat Kinase 1 (LRRK1)ELISA Kit Customized Service Offer
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Skin.
  3. "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain."Cell. Signal. 18:910-920(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract], Macrophage and Spleen.
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract].
  6. "Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers."PLoS ONE 7:E43472-E43472(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]