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Klotho is a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in aging. Its discovery was documented in 1997 by Kuro-o et al. The name of the gene comes from Klotho or Clotho, one of the Moirae, or Fates, in Greek mythology.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH757Hu01 | Recombinant Klotho (KL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH757Hu01 | Polyclonal Antibody to Klotho (KL) | WB; IHC; ICC; IP. |
| MAH757Hu21 | Monoclonal Antibody to Klotho (KL) | WB | |
| Assay Kits | SEH757Hu | ELISA Kit for Klotho (KL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCH757Hu | CLIA Kit for Klotho (KL) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEH757Hu | High Sensitive ELISA Kit for Klotho (KL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH757Mu01 | Recombinant Klotho (KL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPH757Mu02 | Recombinant Klotho (KL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAH757Mu01 | Polyclonal Antibody to Klotho (KL) | WB; IHC; ICC; IP. |
| PAH757Mu02 | Polyclonal Antibody to Klotho (KL) | WB; IHC; ICC; IP. | |
| LAH757Mu71 | Biotin-Linked Polyclonal Antibody to Klotho (KL) | WB; IHC; ICC. | |
| LAH757Mu81 | FITC-Linked Polyclonal Antibody to Klotho (KL) | WB; IHC; ICC; IF. | |
| Assay Kits | SEH757Mu | ELISA Kit for Klotho (KL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCH757Mu | CLIA Kit for Klotho (KL) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH757Ra01 | Recombinant Klotho (KL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPH757Ra02 | Recombinant Klotho (KL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APH757Ra01 | Active Klotho (KL) | Cell culture; Activity Assays. | |
| Antibodies | PAH757Ra01 | Polyclonal Antibody to Klotho (KL) | WB; IHC; ICC; IP. |
| MAH757Ra21 | Monoclonal Antibody to Klotho (KL) | WB; IHC; ICC; IP. | |
| PAH757Ra02 | Polyclonal Antibody to Klotho (KL) | WB; IHC; ICC; IP. | |
| Assay Kits | SEH757Ra | ELISA Kit for Klotho (KL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Mutation of the mouse klotho gene leads to a syndrome resembling ageing."Nature 390:45-51(1997) [PubMed] [Europe PMC] [Abstract]
- "Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein."Biochem. Biophys. Res. Commun. 242:626-630(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
- "Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys."Biochem. Biophys. Res. Commun. 267:597-602(2000) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning and expression of a novel klotho-related protein."J. Mol. Med. 78:389-394(2000) [PubMed] [Europe PMC] [Abstract]
- "Severely reduced production of klotho in human chronic renal failure kidney."Biochem. Biophys. Res. Commun. 280:1015-1020(2001) [PubMed] [Europe PMC] [Abstract]
- "Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane."FEBS Lett. 565:143-147(2004) [PubMed] [Europe PMC] [Abstract]
- "Association of human aging with a functional variant of klotho."Proc. Natl. Acad. Sci. U.S.A. 99:856-861(2002) [PubMed] [Europe PMC] [Abstract]
- "Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity."Circ. Res. 96:412-418(2005) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
- "A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis."J. Clin. Invest. 117:2684-2691(2007) [PubMed] [Europe PMC] [Abstract]