Isocitrate Dehydrogenase 1, Soluble (IDH1)
[Edit]PICD; IDP; Oxalosuccinate decarboxylase; NADP(+)-specific ICDH; Cytosolic NADP-isocitrate dehydrogenase
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Each NADP(+)-dependent isozyme is a homodimer.
IDH1 is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH839Mu01 | Recombinant Isocitrate Dehydrogenase 1, Soluble (IDH1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH839Mu01 | Polyclonal Antibody to Isocitrate Dehydrogenase 1, Soluble (IDH1) | WB; IHC; ICC; IP. |
| LAH839Mu81 | FITC-Linked Polyclonal Antibody to Isocitrate Dehydrogenase 1, Soluble (IDH1) | WB; IHC; ICC; IF. | |
| LAH839Mu71 | Biotin-Linked Polyclonal Antibody to Isocitrate Dehydrogenase 1, Soluble (IDH1) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Isocitrate Dehydrogenase 1, Soluble (IDH1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Isocitrate Dehydrogenase 1, Soluble (IDH1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH839Ra01 | Recombinant Isocitrate Dehydrogenase 1, Soluble (IDH1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH839Ra01 | Polyclonal Antibody to Isocitrate Dehydrogenase 1, Soluble (IDH1) | WB; IHC; ICC; IP. |
| MAH839Ra21 | Monoclonal Antibody to Isocitrate Dehydrogenase 1, Soluble (IDH1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEH839Ra | ELISA Kit for Isocitrate Dehydrogenase 1, Soluble (IDH1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- , Submitted (DEC-2008) to UniProtKB
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