15-Hydroxyprostaglandin Dehydrogenase (HPGD)

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SDR36C1; PGDH1; 15-PGDH; Prostaglandin dehydrogenase 1; Short Chain Dehydrogenase/Reductase Family 36C,Member 1

15-Hydroxyprostaglandin Dehydrogenase (HPGD)
Prostaglandins are involved in many physiologic and cellular processes, such as inflammation. Pichaud et al. (1997) noted that the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH, type I) is the main enzyme of prostaglandin degradation. By catalyzing the conversion of the 15-hydroxyl group of prostaglandins into a keto group, this ubiquitous enzyme strongly reduces the biologic activity of these molecules. The nucleotide sequence coding for PGDH1 was established by Ensor et al. (1990) who found an 801-bp open reading frame coding for a protein with 266 amino acids identical to the amino acid sequence established by Krook et al. (1990).Cortisol reduces the activity of PGDH in human placental cells. 11-beta hydroxysteroid dehydrogenase type II (HSD11B2) converts cortisol to cortisone.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)CLIA Kit Customized Service Offer
n/aELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)CLIA Kit Customized Service Offer
n/aELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)CLIA Kit Customized Service Offer
n/aELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)ELISA Kit Customized Service Offer
  1. "Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family."Biochemistry 29:738-743(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase."J. Biol. Chem. 265:14888-14891(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase."Gene 162:319-322(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA."Gene 188:143-148(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme."Biochem. Biophys. Res. Commun. 176:840-845(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation."J. Biol. Chem. 275:25372-25380(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term."J. Clin. Endocrinol. Metab. 88:2922-2933(2003) [PubMed] [Europe PMC] [Abstract]
  11. "15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers."Proc. Natl. Acad. Sci. U.S.A. 101:17468-17473(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2."Bioorg. Med. Chem. 14:6486-6491(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)."FEBS Lett. 322:139-142(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy."Nat. Genet. 40:789-793(2008) [PubMed] [Europe PMC] [Abstract]
  15. ErratumNat. Genet. 40:927-927(2008)
  16. "High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships."PLoS ONE 5:E13719-E13719(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)."J. Med. Genet. 46:14-20(2009) [PubMed] [Europe PMC] [Abstract]