≡

15-Hydroxyprostaglandin Dehydrogenase (HPGD)

[Edit]

SDR36C1; PGDH1; 15-PGDH; Prostaglandin dehydrogenase 1; Short Chain Dehydrogenase/Reductase Family 36C,Member 1

15-Hydroxyprostaglandin Dehydrogenase (HPGD)
CCC H885
HGNC 5154
MGI 108085
PubMed 24694755
RGD 620087
UniProt P15428
Wiki HPGD
Prostaglandins are involved in many physiologic and cellular processes, such as inflammation. Pichaud et al. (1997) noted that the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH, type I) is the main enzyme of prostaglandin degradation. By catalyzing the conversion of the 15-hydroxyl group of prostaglandins into a keto group, this ubiquitous enzyme strongly reduces the biologic activity of these molecules. The nucleotide sequence coding for PGDH1 was established by Ensor et al. (1990) who found an 801-bp open reading frame coding for a protein with 266 amino acids identical to the amino acid sequence established by Krook et al. (1990).Cortisol reduces the activity of PGDH in human placental cells. 11-beta hydroxysteroid dehydrogenase type II (HSD11B2) converts cortisol to cortisone.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD) CLIA Kit Customized Service Offer
n/a ELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD) CLIA Kit Customized Service Offer
n/a ELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD) CLIA Kit Customized Service Offer
n/a ELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD) ELISA Kit Customized Service Offer
  1. "Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family."Biochemistry 29:738-743(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase."J. Biol. Chem. 265:14888-14891(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase."Gene 162:319-322(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA."Gene 188:143-148(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme."Biochem. Biophys. Res. Commun. 176:840-845(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation."J. Biol. Chem. 275:25372-25380(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term."J. Clin. Endocrinol. Metab. 88:2922-2933(2003) [PubMed] [Europe PMC] [Abstract]
  11. "15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers."Proc. Natl. Acad. Sci. U.S.A. 101:17468-17473(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2."Bioorg. Med. Chem. 14:6486-6491(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)."FEBS Lett. 322:139-142(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy."Nat. Genet. 40:789-793(2008) [PubMed] [Europe PMC] [Abstract]
  15. ErratumNat. Genet. 40:927-927(2008)
  16. "High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships."PLoS ONE 5:E13719-E13719(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)."J. Med. Genet. 46:14-20(2009) [PubMed] [Europe PMC] [Abstract]