Goosecoid (GSC)

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Homeobox protein goosecoid

Goosecoid (GSC)
'Goosecoid' was cloned from a cDNA library constructed from isolated dorsal lip tissue of Xenopus laevis gastrula stage embryos. It encodes a homeodomain transcription factor with DNA binding specificity identical to that of the anterior morphogen 'bicoid' in Drosophila. 'Goosecoid' RNA expression in the dorsal lip of the frog embryo marks the Spemann organizer tissue, which in classic experiments was shown upon transplantation to the ventral side of a recipient embryo to induce formation of a secondary body axis. Injection of synthetic 'goosecoid' mRNA into early Xenopus embryos results in a similar phenotype. Genes homologous to 'goosecoid' have been isolated from mouse, zebrafish, and chick, in all of which the gene is expressed and plays an important role during the process of gastrulation in early embryonic development.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Goosecoid (GSC)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Goosecoid (GSC)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Goosecoid (GSC)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Goosecoid (GSC)CLIA Kit Customized Service Offer
n/aELISA Kit for Goosecoid (GSC)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Goosecoid (GSC)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Goosecoid (GSC)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Goosecoid (GSC)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Goosecoid (GSC)CLIA Kit Customized Service Offer
n/aELISA Kit for Goosecoid (GSC)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Goosecoid (GSC)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Goosecoid (GSC)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Goosecoid (GSC)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Goosecoid (GSC)CLIA Kit Customized Service Offer
n/aELISA Kit for Goosecoid (GSC)ELISA Kit Customized Service Offer
  1. "Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1."Genomics 21:388-393(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid."Am. J. Hum. Genet. 93:1135-1142(2013) [PubMed] [Europe PMC] [Abstract]
  4. "Solution structure of the homeobox domain of homeobox protein goosecoid."Submitted (OCT-2006) to the PDB data bank