GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)

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KIR; Kinase-Inducible Ras-Like Protein; GTP-binding mitogen-induced T-cell protein; GTP-binding protein GEM

GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)
GEM and RAD, the product of a gene overexpressed in skeletal muscle and in individuals with type II diabetes mellitus, constitute a new family of RAS-related GTP-binding proteins. The distinct structural features of this family include the GTP-binding motif, extensive amino- and carboxyl-terminal extensions beyond the RAS-related domain, and a motif that determines membrane association. GEM was transiently expressed in human peripheral blood T cells in response to mitogen stimulation; the protein was phosphorylated on tyrosine residues and localized to the cytosolic face of the plasma membrane. Deregulated GEM expression prevented proliferation of normal and transformed NIH 3T3 cells. These results suggested that GEM is a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)CLIA Kit Customized Service Offer
n/aELISA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)CLIA Kit Customized Service Offer
n/aELISA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)ELISA Kit Customized Service Offer
  1. "Gem: an induced, immediate early protein belonging to the Ras family."Science 265:241-244(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases."Proc. Natl. Acad. Sci. U.S.A. 91:12448-12452(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II."J. Biol. Chem. 272:11832-11839(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway."J. Cell Biol. 157:291-302(2002) [PubMed] [Europe PMC] [Abstract]