Biglycan (BGN)

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DSPG1; PG-S1; PGI; SLRR1A; Biglycan Proteoglycan; Bone/cartilage proteoglycan I

Biglycan (BGN)
Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon.Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS), with DS being more abundant in most connective tissues. The CS/DS chains are attached at amino acids 5 and 10 in human biglycan. The composition of the GAG chains has been reported as varying according to tissue of origin. Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage.The structure of biglycan core protein is highly conserved across species; over 90% homology has been reported for rat, mouse, bovine and human biglycan core proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ226Hu01 Recombinant Biglycan (BGN) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ226Hu02 Recombinant Biglycan (BGN) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ226Hu03 Recombinant Biglycan (BGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ226Hu01 Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC; IP.
PAJ226Hu02 Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC; IP.
LAJ226Hu71 Biotin-Linked Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC.
Assay Kits SEJ226Hu ELISA Kit for Biglycan (BGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ226Mu01 Recombinant Biglycan (BGN) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ226Mu02 Recombinant Biglycan (BGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ226Mu01 Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC; IP.
PAJ226Mu02 Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC; IP.
LAJ226Mu71 Biotin-Linked Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC.
Assay Kits SEJ226Mu ELISA Kit for Biglycan (BGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ226Ra01 Recombinant Biglycan (BGN) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ226Ra02 Recombinant Biglycan (BGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ226Ra01 Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC; IP.
PAJ226Ra02 Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC; IP.
LAJ226Ra71 Biotin-Linked Polyclonal Antibody to Biglycan (BGN) WB; IHC; ICC.
MAJ226Ra21 Monoclonal Antibody to Biglycan (BGN) WB; IHC; ICC; IP.
Assay Kits SEJ226Ra ELISA Kit for Biglycan (BGN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species."J. Biol. Chem. 264:4571-4576(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization."J. Biol. Chem. 266:14371-14377(1991) [PubMed] [Europe PMC] [Abstract]
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  7. "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."J. Biol. Chem. 262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Dinucleotide repeat polymorphism at the human biglycan (BGN) locus."Hum. Mol. Genet. 3:2268-2268(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
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