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Carbohydrate Sulfotransferase 3 (CHST3)

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C6ST; C6ST1; GST-0; Chondroitin 6 Sulfotransferase 3; Chondroitin 6-O-sulfotransferase 1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0

Carbohydrate Sulfotransferase 3 (CHST3)
CCC J393
HGNC 1971
MGI 1858224
PubMed 20830804
RGD 620355
UniProt Q7LGC8
Chondroitin sulfate proteoglycans, which consist of a core protein with at least 1 covalently attached glycosaminoglycan (GAG) chain, are distributed on the surfaces of most cells and the extracellular matrix in virtually every tissue.Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate from PAPS (3-prime-phosphoadenosine 5-prime-phosphosulfate) to position 6 of the GalNAc residues.
The predicted 479-amino acid protein shares 74% and 36% identity with chick C6ST and human keratan sulfate gal-6-sulfotransferase (CHST1), respectively. Recombinant human enzyme displayed C6ST activity with a marked specificity for a GlcA-GalNAc sequence. In addition, C6ST catalyzed the sulfation of keratan sulfate.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 3 (CHST3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 3 (CHST3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 3 (CHST3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 3 (CHST3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 3 (CHST3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 3 (CHST3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 3 (CHST3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 3 (CHST3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 3 (CHST3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 3 (CHST3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 3 (CHST3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 3 (CHST3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 3 (CHST3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 3 (CHST3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 3 (CHST3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of human chondroitin 6-sulfotransferase."Biochim. Biophys. Acta 1399:57-61(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Functional expression and genomic structure of human chondroitin 6-sulfotransferase."FEBS Lett. 441:235-241(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement."Proc. Natl. Acad. Sci. U.S.A. 101:10155-10160(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Congenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis."Am. J. Hum. Genet. 82:1368-1374(2008) [PubMed] [Europe PMC] [Abstract]
  6. ErratumAm. J. Hum. Genet. 83:293-293(2008)