1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)

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1-AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-Beta; Lysophosphatidic Acid Acyltransferase,Beta; Berardinelli-Seip Congenital Lipodystrophy

1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)
AGPAT2is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.The predicted LPAAT-beta protein is 278 amino acids long. Overall, the sequences of the 2 human proteins are 12% identical to the sequence of yeast LPAAT.LPAAT-beta is expressed in a distinct tissue-specific pattern, with the highest levels of expression observed in liver and heart.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)CLIA Kit Customized Service Offer
n/aELISA Kit for 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)CLIA Kit Customized Service Offer
n/aELISA Kit for 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)CLIA Kit Customized Service Offer
n/aELISA Kit for 1-Acylglycerol-3-Phosphate-O-Acyltransferase 2 (AGPAT2)ELISA Kit Customized Service Offer
  1. "Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3."J. Biol. Chem. 272:20299-20305(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases."Biochem. J. 326:455-461(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells."DNA Cell Biol. 16:691-701(1997) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Acquired and inherited lipodystrophies."N. Engl. J. Med. 350:1220-1234(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy."Biochem. Biophys. Res. Commun. 327:446-453(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice."J. Biol. Chem. 286:37676-37691(2011) [PubMed] [Europe PMC] [Abstract]
  10. "AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34."Nat. Genet. 31:21-23(2002) [PubMed] [Europe PMC] [Abstract]