Ets Variant 6 (ETV6)

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TEL; TEL/ABL; ETS translocation variant 6; ETS-related protein Tel1; Transcription factor ETV6

Ets Variant 6 (ETV6)
ETV6 encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. Portions of the gene showed homology to the ETS family of transcription factors, and it was designated 'TEL' for translocation, ETS, leukemia. Northern blot analysis detected 3 transcripts of 6.5 kb, 4.5 kb, and 2.4 kb in all tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ets Variant 6 (ETV6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ets Variant 6 (ETV6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ets Variant 6 (ETV6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ets Variant 6 (ETV6)CLIA Kit Customized Service Offer
n/aELISA Kit for Ets Variant 6 (ETV6)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ets Variant 6 (ETV6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ets Variant 6 (ETV6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ets Variant 6 (ETV6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ets Variant 6 (ETV6)CLIA Kit Customized Service Offer
n/aELISA Kit for Ets Variant 6 (ETV6)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ets Variant 6 (ETV6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ets Variant 6 (ETV6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ets Variant 6 (ETV6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ets Variant 6 (ETV6)CLIA Kit Customized Service Offer
n/aELISA Kit for Ets Variant 6 (ETV6)ELISA Kit Customized Service Offer
  1. "Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation."Cell 77:307-316(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization of TEL: the human ETS-variant gene 6."Genome Res. 6:404-413(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia."Nature 446:758-764(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia."Proc. Natl. Acad. Sci. U.S.A. 92:4917-4921(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion."Blood 85:3662-3670(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)."Genes Chromosomes Cancer 26:192-202(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13)."Blood 94:1820-1824(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Functional regulation of TEL by p38-induced phosphorylation."Biochem. Biophys. Res. Commun. 299:116-125(2002) [PubMed] [Europe PMC] [Abstract]
  11. "A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome."Genes Chromosomes Cancer 35:11-19(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta."N. Engl. J. Med. 347:481-487(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)."J. Biol. Chem. 278:15412-15420(2003) [PubMed] [Europe PMC] [Abstract]
  14. "The histone deacetylase 9 gene encodes multiple protein isoforms."J. Biol. Chem. 278:16059-16072(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia."Oncogene 24:4129-4137(2005) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy." Nat. Genet. 47:180-185(2015) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of ets domain transcriptional factor ETV6 protein."Submitted (DEC-2006) to the PDB data bank