Ewing Sarcoma Breakpoint Region 1 (EWSR1)

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EWS; RNA-binding protein EWS; EWS oncogene

Ewing Sarcoma Breakpoint Region 1 (EWSR1)
EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ewing Sarcoma Breakpoint Region 1 (EWSR1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ewing Sarcoma Breakpoint Region 1 (EWSR1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ewing Sarcoma Breakpoint Region 1 (EWSR1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ewing Sarcoma Breakpoint Region 1 (EWSR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Ewing Sarcoma Breakpoint Region 1 (EWSR1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ewing Sarcoma Breakpoint Region 1 (EWSR1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ewing Sarcoma Breakpoint Region 1 (EWSR1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ewing Sarcoma Breakpoint Region 1 (EWSR1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ewing Sarcoma Breakpoint Region 1 (EWSR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Ewing Sarcoma Breakpoint Region 1 (EWSR1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ewing Sarcoma Breakpoint Region 1 (EWSR1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ewing Sarcoma Breakpoint Region 1 (EWSR1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ewing Sarcoma Breakpoint Region 1 (EWSR1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ewing Sarcoma Breakpoint Region 1 (EWSR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Ewing Sarcoma Breakpoint Region 1 (EWSR1)ELISA Kit Customized Service Offer
  1. "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours."Nature 359:162-165(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation."Genomics 18:609-615(1993) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region."Genomics 38:247-254(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein."J. Biol. Chem. 276:18681-18687(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma."Genes Chromosomes Cancer 13:126-132(1995) [PubMed] [Europe PMC] [Abstract]
  10. , Submitted (DEC-2008) to UniProtKB
  11. "The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain."J. Biol. Chem. 272:27369-27377(1997) [PubMed] [Europe PMC] [Abstract]
  12. "The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains."Oncogene 9:3087-3097(1994) [PubMed] [Europe PMC] [Abstract]
  13. "A new member of the ETS family fused to EWS in Ewing tumors."Oncogene 14:1159-1164(1997) [PubMed] [Europe PMC] [Abstract]
  14. "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription."J. Biol. Chem. 273:18086-18091(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Transcriptional activation by the Ewing's sarcoma (EWS) oncogene can be cis-repressed by the EWS RNA-binding domain."J. Biol. Chem. 275:23053-23058(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma."Cell Cycle 5:2753-2759(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein."J. Mol. Biol. 363:27-38(2006) [PubMed] [Europe PMC] [Abstract]
  18. "TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules."Hum. Mol. Genet. 17:3055-3074(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state."Proteins 72:1125-1137(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of the RNA recognition motif of Ewing sarcoma (EWS) protein."Submitted (NOV-2005) to the PDB data bank
  24. "Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma."Genes Chromosomes Cancer 44:97-102(2005) [PubMed] [Europe PMC] [Abstract]
  25. "EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma."Genes Chromosomes Cancer 46:1051-1060(2007) [PubMed] [Europe PMC] [Abstract]