Fanconi Anemia Complementation Group G (FANCG)

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FAG; XRCC9; DNA Repair Protein XRCC9; X-Ray Repair,Complementing Defective,In Chinese Hamster 9

Fanconi Anemia Complementation Group G (FANCG)
FANCG, involved in Fanconi anemia, confers resistance to both hygromycin and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies. A minimum of 8 FA genes have been identified. The putative 622-amino acid protein has a leucine zipper motif at its N terminus, but the authors found no significant similarity to any known protein. In human and baboon tissues, 2 major mRNA bands of 2.2 and 2.5 kb were detected, with highest levels in testis and thymus in human, and in testis in baboon.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fanconi Anemia Complementation Group G (FANCG)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fanconi Anemia Complementation Group G (FANCG)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fanconi Anemia Complementation Group G (FANCG)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fanconi Anemia Complementation Group G (FANCG)CLIA Kit Customized Service Offer
n/aELISA Kit for Fanconi Anemia Complementation Group G (FANCG)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fanconi Anemia Complementation Group G (FANCG)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fanconi Anemia Complementation Group G (FANCG)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fanconi Anemia Complementation Group G (FANCG)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fanconi Anemia Complementation Group G (FANCG)CLIA Kit Customized Service Offer
n/aELISA Kit for Fanconi Anemia Complementation Group G (FANCG)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fanconi Anemia Complementation Group G (FANCG)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fanconi Anemia Complementation Group G (FANCG)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fanconi Anemia Complementation Group G (FANCG)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fanconi Anemia Complementation Group G (FANCG)CLIA Kit Customized Service Offer
n/aELISA Kit for Fanconi Anemia Complementation Group G (FANCG)ELISA Kit Customized Service Offer
  1. "The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells."Proc. Natl. Acad. Sci. U.S.A. 94:9232-9237(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The Fanconi anaemia group G gene FANCG is identical with XRCC9."Nat. Genet. 20:281-283(1998) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex."Mol. Cell. Biol. 19:4866-4873(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome."Mol. Cell. Biol. 23:3417-3426(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR)."J. Biol. Chem. 279:43910-43919(2004) [PubMed] [Europe PMC] [Abstract]
  8. "X-linked inheritance of Fanconi anemia complementation group B."Nat. Genet. 36:1219-1224(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M."Nat. Genet. 37:958-963(2005) [PubMed] [Europe PMC] [Abstract]
  10. "FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3."Oncogene 27:3641-3652(2008) [PubMed] [Europe PMC] [Abstract]
  11. "FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway."Blood 119:3285-3294(2012) [PubMed] [Europe PMC] [Abstract]
  12. "A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network."Mol. Cell 47:61-75(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of Rev1 by the Fanconi anemia core complex."Nat. Struct. Mol. Biol. 19:164-170(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9."Eur. J. Hum. Genet. 8:861-868(2000) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  16. "HES1 is a novel interactor of the Fanconi anemia core complex."Blood 112:2062-2070(2008) [PubMed] [Europe PMC] [Abstract]