FIP1 Like Protein 1 (FIP1L1)

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Rhe; Pre-mRNA 3'-end-processing factor FIP1; Factor interacting with PAP; Rearranged in hypereosinophilia

FIP1 Like Protein 1 (FIP1L1)
FIP1L1encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant FIP1 Like Protein 1 (FIP1L1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to FIP1 Like Protein 1 (FIP1L1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to FIP1 Like Protein 1 (FIP1L1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for FIP1 Like Protein 1 (FIP1L1)CLIA Kit Customized Service Offer
n/aELISA Kit for FIP1 Like Protein 1 (FIP1L1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant FIP1 Like Protein 1 (FIP1L1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to FIP1 Like Protein 1 (FIP1L1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to FIP1 Like Protein 1 (FIP1L1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for FIP1 Like Protein 1 (FIP1L1)CLIA Kit Customized Service Offer
n/aELISA Kit for FIP1 Like Protein 1 (FIP1L1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant FIP1 Like Protein 1 (FIP1L1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to FIP1 Like Protein 1 (FIP1L1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to FIP1 Like Protein 1 (FIP1L1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for FIP1 Like Protein 1 (FIP1L1)CLIA Kit Customized Service Offer
n/aELISA Kit for FIP1 Like Protein 1 (FIP1L1)ELISA Kit Customized Service Offer
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  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome."Proc. Natl. Acad. Sci. U.S.A. 100:7830-7835(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein."J. Virol. 79:4270-4288(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome." N. Engl. J. Med. 348:1201-1214(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]