Paired Like Homeobox Protein 2B (PHOX2B)

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PMX2B; Phox2b; NBPhox; Paired Mesoderm Homeobox 2b; Neuroblastoma Phox; Paired-like homeobox 2B

Paired Like Homeobox Protein 2B (PHOX2B)
PHOX2B contains an open reading frame of 314 amino acids spanning nucleotides 361 to 1,302. The polyadenylation signal AATAAA is located 17 bases upstream from the site of polyadenylation. The gene encodes a novel protein with a homeodomain that is significantly homologous with those in the various members of the paired-type homeobox genes. The amino acid sequences of the homeodomains of PHOX2B and PHOX2A each cover 60 amino acids and are a perfect match, but outside the homeodomain no significant sequence similarity was observed. A proline-rich domain lies between amino acids 192 and 284 of the PHOX2B protein, and a glycine-rich domain lies between amino acids 196 and 289. There are 2 alanine-rich repeats in the C terminus of the homeodomain.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Like Homeobox Protein 2B (PHOX2B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Like Homeobox Protein 2B (PHOX2B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Like Homeobox Protein 2B (PHOX2B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Like Homeobox Protein 2B (PHOX2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Like Homeobox Protein 2B (PHOX2B)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Like Homeobox Protein 2B (PHOX2B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Like Homeobox Protein 2B (PHOX2B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Like Homeobox Protein 2B (PHOX2B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Like Homeobox Protein 2B (PHOX2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Like Homeobox Protein 2B (PHOX2B)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Like Homeobox Protein 2B (PHOX2B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Like Homeobox Protein 2B (PHOX2B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Like Homeobox Protein 2B (PHOX2B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Like Homeobox Protein 2B (PHOX2B)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Like Homeobox Protein 2B (PHOX2B)ELISA Kit Customized Service Offer
  1. "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles."DNA Res. 3:311-320(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription."DNA Cell Biol. 19:539-554(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation."Genomics 59:40-50(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular analysis of congenital central hypoventilation syndrome."Hum. Genet. 114:22-26(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome."Nat. Genet. 33:459-461(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma."Am. J. Hum. Genet. 74:761-764(2004) [PubMed] [Europe PMC] [Abstract]
  8. "PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome."Am. J. Hum. Genet. 76:421-426(2005) [PubMed] [Europe PMC] [Abstract]
  9. ErratumAm. J. Hum. Genet. 76:715-715(2002)
  10. "PHOX2B analysis in non-syndromic neuroblastoma cases shows novel mutations and genotype-phenotype associations."Am. J. Med. Genet. A 140:1297-1301(2006) [PubMed] [Europe PMC] [Abstract]