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Succinate Dehydrogenase Complex Subunit B (SDHB)

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SDH1; SDH; Ip; Iron Sulfur; Iron-sulfur subunit of complex II; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Succinate Dehydrogenase Complex Subunit B (SDHB)
CCC J756
HGNC 10681
MGI 1914930
PubMed 21934479
RGD 1308598
UniProt P21912
Wiki SDHB
Complex II in mitochondria, of which succinate dehydrogenase (EC 1.3.99.1) is a component, has 4 subunits. In order of decreasing molecular mass, they are the flavoprotein (SDHA), the iron sulfur protein (SDHB), and the 2 integral membrane proteins, SDHC and SDHD.
Kita et al. (1990) cloned and sequenced the iron sulfur protein subunit. A clone was isolated from a human liver cDNA library. The open reading frame encodes a 252-amino acid protein. The amino acid sequence showed approximately 94% homology with that of bovine heart. Au et al. (1995) described the complete genomic clone for the gene encoding the iron sulfur protein subunit.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ756Hu01 Recombinant Succinate Dehydrogenase Complex Subunit B (SDHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit B (SDHB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit B (SDHB) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ756Hu ELISA Kit for Succinate Dehydrogenase Complex Subunit B (SDHB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ756Mu01 Recombinant Succinate Dehydrogenase Complex Subunit B (SDHB) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ756Mu02 Recombinant Succinate Dehydrogenase Complex Subunit B (SDHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ756Mu01 Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit B (SDHB) WB; IHC; ICC; IP.
PAJ756Mu02 Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit B (SDHB) WB; IHC; ICC; IP.
Assay Kits SEJ756Mu ELISA Kit for Succinate Dehydrogenase Complex Subunit B (SDHB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Succinate Dehydrogenase Complex Subunit B (SDHB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit B (SDHB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit B (SDHB) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ756Ra ELISA Kit for Succinate Dehydrogenase Complex Subunit B (SDHB) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase."Gene 159:249-253(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Housekeeping genes for phylogenetic analysis of eutherian relationships."Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria."Biochem. Biophys. Res. Commun. 166:101-108(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species."Proc. Natl. Acad. Sci. U.S.A. 86:1934-1938(1989) [PubMed] [Europe PMC] [Abstract]
  8. ErratumProc. Natl. Acad. Sci. U.S.A. 90:2556-2556(1993)
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma."Am. J. Hum. Genet. 69:49-54(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene."J. Clin. Endocrinol. Metab. 87:4101-4105(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas."J. Med. Genet. 39:178-183(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Germ-line mutations in nonsyndromic pheochromocytoma." N. Engl. J. Med. 346:1459-1466(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas."Cancer Res. 63:5615-5621(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility."Clin. Endocrinol. (Oxf.) 59:728-733(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas."Oncogene 22:1358-1364(2003) [PubMed] [Europe PMC] [Abstract]
  18. "K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma."Clin. Endocrinol. (Oxf.) 61:510-514(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations."JAMA 292:943-951(2004) [PubMed] [Europe PMC] [Abstract]
  20. ErratumJAMA 292:1686-1686(2004)
  21. "A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas."J. Clin. Endocrinol. Metab. 89:362-367(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Somatic SDHB mutation in an extraadrenal pheochromocytoma."N. Engl. J. Med. 357:306-308(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Familial gastrointestinal stromal tumors and germ-line mutations."N. Engl. J. Med. 357:1054-1056(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes."Am. J. Hum. Genet. 83:261-268(2008) [PubMed] [Europe PMC] [Abstract]