Succinate Dehydrogenase Complex Subunit A (SDHA)

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SDH2; SDHF; FP; Flavoprotein; Flavoprotein subunit of complex II; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Succinate Dehydrogenase Complex Subunit A (SDHA)
SDHA encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29.
Hirawake et al. (1994) isolated a cDNA corresponding to the flavoprotein subunit of SDH from a human liver cDNA library. The deduced 621-amino acid protein has a molecular mass of approximately 68 kD and shows high homology to the bovine heart flavoprotein subunit.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Succinate Dehydrogenase Complex Subunit A (SDHA)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Succinate Dehydrogenase Complex Subunit A (SDHA)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Succinate Dehydrogenase Complex Subunit A (SDHA)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Succinate Dehydrogenase Complex Subunit A (SDHA)CLIA Kit Customized Service Offer
n/aELISA Kit for Succinate Dehydrogenase Complex Subunit A (SDHA)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPJ784Mu01Recombinant Succinate Dehydrogenase Complex Subunit A (SDHA)SDS-PAGE; WB; ELISA; IP.
RPJ784Mu02Recombinant Succinate Dehydrogenase Complex Subunit A (SDHA)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAJ784Mu01Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit A (SDHA)WB, ICC, IHC-P, IHC-F, ELISA
PAJ784Mu02Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit A (SDHA)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEJ784MuELISA Kit for Succinate Dehydrogenase Complex Subunit A (SDHA)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Succinate Dehydrogenase Complex Subunit A (SDHA)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Succinate Dehydrogenase Complex Subunit A (SDHA)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Succinate Dehydrogenase Complex Subunit A (SDHA)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Succinate Dehydrogenase Complex Subunit A (SDHA)CLIA Kit Customized Service Offer
n/aELISA Kit for Succinate Dehydrogenase Complex Subunit A (SDHA)ELISA Kit Customized Service Offer
  1. "Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria."J. Biochem. 116:221-227(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase."Biochim. Biophys. Acta 1185:125-128(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Compound heterozygous mutations in the flavoprotein gene of the respiratory chain complex II in a patient with Leigh syndrome."Hum. Genet. 106:236-243(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning of the flavoprotein subunit of human succinate dehydrogenase."(In) Curti B., Ronchi S., Zanetti G. (eds.);Flavins and flavoproteins 1990, pp.727-730, Walter de Gruyter, Berlin (1991)
  8. "Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency."Nat. Genet. 11:144-149(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
  10. "SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma."Science 325:1139-1142(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "SDHA is a tumor suppressor gene causing paraganglioma."Hum. Mol. Genet. 19:3011-3020(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components."Biochem. J. 447:281-289(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase."Cell Metab. 17:988-999(2013) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Homozygous Gly555Glu mutation in the nuclear-encoded 70 kDa flavoprotein gene causes instability of the respiratory chain complex II."Am. J. Med. Genet. A 120:13-18(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase."Eur. J. Hum. Genet. 18:1160-1165(2010) [PubMed] [Europe PMC] [Abstract]