Distal Less Homeobox Protein 5 (DLX5)
DLX5 may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
Msx2 associated with transcriptionally repressed OC chromatin, and Dlx3 and Dlx5 were recruited with Runx2 to initiate OC transcription. In a second regulatory switch, Dlx3 association decreased and Dlx5 recruitment increased coincident with the mineralization stage of osteoblast differentiation. The appearance of Dlx3 followed by Dlx5 in the OC promoter correlated with increased transcription represented by increased occupancy of RNA polymerase II.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Distal Less Homeobox Protein 5 (DLX5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Distal Less Homeobox Protein 5 (DLX5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Distal Less Homeobox Protein 5 (DLX5)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Distal Less Homeobox Protein 5 (DLX5)CLIA Kit Customized Service Offer
n/aELISA Kit for Distal Less Homeobox Protein 5 (DLX5)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Distal Less Homeobox Protein 5 (DLX5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Distal Less Homeobox Protein 5 (DLX5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Distal Less Homeobox Protein 5 (DLX5)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Distal Less Homeobox Protein 5 (DLX5)CLIA Kit Customized Service Offer
n/aELISA Kit for Distal Less Homeobox Protein 5 (DLX5)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Distal Less Homeobox Protein 5 (DLX5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Distal Less Homeobox Protein 5 (DLX5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Distal Less Homeobox Protein 5 (DLX5)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Distal Less Homeobox Protein 5 (DLX5)CLIA Kit Customized Service Offer
n/aELISA Kit for Distal Less Homeobox Protein 5 (DLX5)ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and characterization of two members of the vertebrate Dlx gene family."Proc. Natl. Acad. Sci. U.S.A. 91:2250-2254(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex."J. Biol. Chem. 277:37280-37291(2002) [PubMed] [Europe PMC] [Abstract]
  6. "DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC."J. Biol. Chem. 284:20593-20601(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The solution structure of the homeobox domain of human homeobox protein DLX-5."Submitted (OCT-2006) to the PDB data bank
  8. "Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation."J. Med. Genet. 49:16-20(2012) [PubMed] [Europe PMC] [Abstract]