Engrailed Homeobox Protein 2 (EN2)

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AUTS1

Engrailed Homeobox Protein 2 (EN2)
Prostate cancer (PC) is the second most common cause of cancer related death in men. A number of key limitations with prostate specific antigen (PSA), currently the standard detection test, has justified evaluation of new biomarkers.Engrailed-2 (EN2) protein, a homeodomain-containing transcription factor expressed in PC cell lines and secreted into the urine by PC in men. EN2 was expressed and secreted by PC cell lines and PC tissue but not by normal prostate tissue or stroma. The presence of EN2 in urine was highly predictive of PC, with a sensitivity of 66% and a specificity of 88.2%, without requirement for DRE. There was no correlation with PSA levels.Urinary EN2 is a highly specific and sensitive candidate biomarker of prostate cancer.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPJ982Hu01Recombinant Engrailed Homeobox Protein 2 (EN2)SDS-PAGE; WB; ELISA; IP.
CPJ982Hu21OVA Conjugated Engrailed Homeobox Protein 2 (EN2)Immunogen; Coating Antigen; Blocking Peptide; ELISA.
AntibodiesPAJ982Hu01Polyclonal Antibody to Engrailed Homeobox Protein 2 (EN2)WB, ICC, IHC-P, IHC-F, ELISA
MAJ982Hu21Monoclonal Antibody to Engrailed Homeobox Protein 2 (EN2)WB, ICC, IHC-P, IHC-F, ELISA
PAJ982Hu08Polyclonal Antibody to Engrailed Homeobox Protein 2 (EN2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEJ982HuELISA Kit for Engrailed Homeobox Protein 2 (EN2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Engrailed Homeobox Protein 2 (EN2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Engrailed Homeobox Protein 2 (EN2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Engrailed Homeobox Protein 2 (EN2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Engrailed Homeobox Protein 2 (EN2)CLIA Kit Customized Service Offer
n/aELISA Kit for Engrailed Homeobox Protein 2 (EN2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Engrailed Homeobox Protein 2 (EN2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Engrailed Homeobox Protein 2 (EN2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Engrailed Homeobox Protein 2 (EN2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Engrailed Homeobox Protein 2 (EN2)CLIA Kit Customized Service Offer
n/aELISA Kit for Engrailed Homeobox Protein 2 (EN2)ELISA Kit Customized Service Offer
  1. "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and chromosomal localization of the human En-2 gene."Genomics 4:225-231(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus."Am. J. Hum. Genet. 77:851-868(2005) [PubMed] [Europe PMC] [Abstract]