Intestine Specific Homeobox Protein (ISX)

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RAXLX; RAX-like homeobox

Intestine Specific Homeobox Protein (ISX)
Using expression profiling to identify transcription factors involved in development of the mouse digestive tract, Choi et al. (2006) identified a novel gene, which they they named Isx because of its highly restricted expression pattern in the intestine.
This construct showed that Isx is abundantly expressed in intestinal epithelial cells from the duodenum to the proximal colon. Expression profiling showed further that beta-carotene 15,15-prime-monooxygenase (BCMO1) and Scarb1 were highly upregulated in homozygous knockout animals. BCMO1 is involved in vitamin A synthesis and SCARB1 in carotenoid and cholesterol uptake. Vitamin A deprivation of wildtype mice resulted in decreased Isx and increased Bcmo1 expression. Isx participates in vitamin A metabolism most likely by regulating Bcmo1 expression in the intestine.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Intestine Specific Homeobox Protein (ISX)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Intestine Specific Homeobox Protein (ISX)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Intestine Specific Homeobox Protein (ISX)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Intestine Specific Homeobox Protein (ISX)CLIA Kit Customized Service Offer
n/aELISA Kit for Intestine Specific Homeobox Protein (ISX)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Intestine Specific Homeobox Protein (ISX)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Intestine Specific Homeobox Protein (ISX)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Intestine Specific Homeobox Protein (ISX)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Intestine Specific Homeobox Protein (ISX)CLIA Kit Customized Service Offer
n/aELISA Kit for Intestine Specific Homeobox Protein (ISX)ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]