Paired Like Homeobox Protein 2A (PHOX2A)

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ARIX; CFEOM2; FEOM2; NCAM2; PMX2A; ARIX1 homeodomain protein; Aristaless Homeobox Fibrosis Of Extraocular Muscles Congenital 2 Autosomal Recessive

Paired Like Homeobox Protein 2A (PHOX2A)
PHOX2A encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype.
The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Like Homeobox Protein 2A (PHOX2A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Like Homeobox Protein 2A (PHOX2A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Like Homeobox Protein 2A (PHOX2A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Like Homeobox Protein 2A (PHOX2A)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Like Homeobox Protein 2A (PHOX2A)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Like Homeobox Protein 2A (PHOX2A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Like Homeobox Protein 2A (PHOX2A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Like Homeobox Protein 2A (PHOX2A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Like Homeobox Protein 2A (PHOX2A)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Like Homeobox Protein 2A (PHOX2A)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Like Homeobox Protein 2A (PHOX2A)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Like Homeobox Protein 2A (PHOX2A)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Like Homeobox Protein 2A (PHOX2A)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Like Homeobox Protein 2A (PHOX2A)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Like Homeobox Protein 2A (PHOX2A)ELISA Kit Customized Service Offer
  1. "Mapping of the ARIX homeodomain gene to mouse chromosome 7 and human chromosome 11q13."Genomics 33:527-531(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Homozygous mutations in ARIX(PHOX2A) result in congenital fibrosis of the extraocular muscles type 2."Nat. Genet. 29:315-320(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular analysis of congenital central hypoventilation syndrome."Hum. Genet. 114:22-26(2003) [PubMed] [Europe PMC] [Abstract]