Paired Related Homeobox Protein 2 (PRRX2)

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PMX2; PRX2; Paired mesoderm homeobox protein 2

Paired Related Homeobox Protein 2 (PRRX2)
PRRX2 is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The composite 813-nucleotide cDNA encodes a putative 164-amino acid protein with 74% overall identity to mouse Prx2, showing high conservation in the homeodomain and extreme 3-prime region. PRX2 is expressed as a single 1.3-kb transcript. PRX2 is more strongly expressed in normal fetal than in adult skin, much more strongly expressed in both fetal and adult proliferating fibroblasts, and not expressed in keratinocytes.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Related Homeobox Protein 2 (PRRX2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Related Homeobox Protein 2 (PRRX2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Related Homeobox Protein 2 (PRRX2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Related Homeobox Protein 2 (PRRX2)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Related Homeobox Protein 2 (PRRX2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Related Homeobox Protein 2 (PRRX2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Related Homeobox Protein 2 (PRRX2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Related Homeobox Protein 2 (PRRX2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Related Homeobox Protein 2 (PRRX2)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Related Homeobox Protein 2 (PRRX2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Paired Related Homeobox Protein 2 (PRRX2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Paired Related Homeobox Protein 2 (PRRX2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Paired Related Homeobox Protein 2 (PRRX2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Paired Related Homeobox Protein 2 (PRRX2)CLIA Kit Customized Service Offer
n/aELISA Kit for Paired Related Homeobox Protein 2 (PRRX2)ELISA Kit Customized Service Offer
  1. "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome."Mamm. Genome 11:1000-1005(2000) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds."J. Invest. Dermatol. 111:57-63(1998) [PubMed] [Europe PMC] [Abstract]