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Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16)

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PLZF; ZNF145; Zinc Finger Protein 145; Kruppel-Like,Expressed In Promyelocytic Leukemia; Promyelocytic leukemia zinc finger protein

Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16)
CCC K189
HGNC 12930
MGI 103222
PubMed 23446662
RGD 727921
UniProt Q05516
Wiki ZBTB16
ZBTB16is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human. Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger And BTB Domain Containing Protein 16 (ZBTB16) ELISA Kit Customized Service Offer
  1. "Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia."EMBO J. 12:1161-1167(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene."Proc. Natl. Acad. Sci. U.S.A. 96:11422-11427(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia."J. Clin. Invest. 91:2260-2267(1993) [PubMed] [Europe PMC] [Abstract]
  5. "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF."Blood 94:3737-3747(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis."Science 291:1047-1051(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of the BTB domain from PLZF."Proc. Natl. Acad. Sci. U.S.A. 95:12123-12128(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein."Cancer Res. 59:5275-5282(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia."J. Med. Genet. 45:731-737(2008) [PubMed] [Europe PMC] [Abstract]