Fanconi Anemia Complementation Group F (FANCF)

[Edit]

FAF; FACF

Fanconi Anemia Complementation Group F (FANCF)
FANCF was found predominantly in the nucleus, where it complexes with FANCA, FANCC, and FANCG . These interactions were detected in wildtype and FANCD (FANCD2) lymphoblasts, but not in lymphoblasts of other FA complementation groups. The authors hypothesized that each of the FA proteins, except FANCD, is required for complex formation, and that the multiprotein FA complex serves a nuclear function to maintain genomic integrity.FANCF gene encodes a polypeptide with homology to the prokaryotic RNA-binding protein ROM. The region of homology with ROM comprises the N terminus of the prokaryotic protein, which is the region involved in RNA binding. The homologous region in FANCF is predicted to form an alpha-helical structure.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fanconi Anemia Complementation Group F (FANCF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fanconi Anemia Complementation Group F (FANCF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fanconi Anemia Complementation Group F (FANCF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fanconi Anemia Complementation Group F (FANCF)CLIA Kit Customized Service Offer
n/aELISA Kit for Fanconi Anemia Complementation Group F (FANCF)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fanconi Anemia Complementation Group F (FANCF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fanconi Anemia Complementation Group F (FANCF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fanconi Anemia Complementation Group F (FANCF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fanconi Anemia Complementation Group F (FANCF)CLIA Kit Customized Service Offer
n/aELISA Kit for Fanconi Anemia Complementation Group F (FANCF)ELISA Kit Customized Service Offer
  1. "The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM."Nat. Genet. 24:15-16(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex."J. Biol. Chem. 282:2047-2055(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG."Hum. Mol. Genet. 9:2665-2674(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome."Mol. Cell. Biol. 23:3417-3426(2003) [PubMed] [Europe PMC] [Abstract]
  7. "X-linked inheritance of Fanconi anemia complementation group B."Nat. Genet. 36:1219-1224(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M."Nat. Genet. 37:958-963(2005) [PubMed] [Europe PMC] [Abstract]
  9. "HES1 is a novel interactor of the Fanconi anemia core complex."Blood 112:2062-2070(2008) [PubMed] [Europe PMC] [Abstract]