Bloom Syndrome Protein (BLM)

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BS; RECQ2; RECQL2; RECQL3; RecQ Helicase-Like; DNA helicase, RecQ-like type 2

Bloom Syndrome Protein (BLM)
BLM protein is located in the nucleus of normal human cells in the nuclear domain 10 (ND10) or promyelocytic leukemia nuclear bodies. These structures are punctate deposits of proteins disrupted upon viral infection and in certain human malignancies.
BLM was found primarily in ND10 except during S phase, when it colocalized with the WRN gene product, in the nucleolus. BLM colocalized with a select subset of telomeres in normal cells and with large telomeric clusters seen in simian virus 40-transformed normal fibroblasts. During S phase, Bloom syndrome cells expel micronuclei containing sites of DNA synthesis. The BLM protein is likely to be part of a DNA surveillance mechanism operating during S phase.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Bloom Syndrome Protein (BLM)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Bloom Syndrome Protein (BLM)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Bloom Syndrome Protein (BLM)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Bloom Syndrome Protein (BLM)CLIA Kit Customized Service Offer
n/aELISA Kit for Bloom Syndrome Protein (BLM)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Bloom Syndrome Protein (BLM)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Bloom Syndrome Protein (BLM)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Bloom Syndrome Protein (BLM)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Bloom Syndrome Protein (BLM)CLIA Kit Customized Service Offer
n/aELISA Kit for Bloom Syndrome Protein (BLM)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Bloom Syndrome Protein (BLM)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Bloom Syndrome Protein (BLM)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Bloom Syndrome Protein (BLM)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Bloom Syndrome Protein (BLM)CLIA Kit Customized Service Offer
n/aELISA Kit for Bloom Syndrome Protein (BLM)ELISA Kit Customized Service Offer
  1. "The Bloom's syndrome gene product is homologous to RecQ helicases."Cell 83:655-666(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The Bloom's syndrome gene product is a 3'-5' DNA helicase."J. Biol. Chem. 272:30611-30614(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal."Biochem. Biophys. Res. Commun. 240:348-353(1997) [PubMed] [Europe PMC] [Abstract]
  5. "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures."Genes Dev. 14:927-939(2000) [PubMed] [Europe PMC] [Abstract]
  6. "BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks."EMBO J. 23:3154-3163(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The BLM helicase is necessary for normal DNA double-strand break repair."Cancer Res. 62:2766-2770(2002) [PubMed] [Europe PMC] [Abstract]
  8. "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity."EMBO J. 24:1465-1476(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A double Holliday junction dissolvasome comprising BLM, topoisomerase III alpha, and BLAP75."J. Biol. Chem. 281:13861-13864(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality."Mech. Ageing Dev. 128:609-617(2007) [PubMed] [Europe PMC] [Abstract]
  12. "RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability."Genes Dev. 22:2843-2855(2008) [PubMed] [Europe PMC] [Abstract]
  13. "BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome."Genes Dev. 22:2856-2868(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair."Genes Dev. 25:350-362(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair."Proc. Natl. Acad. Sci. U.S.A. 110:10646-10651(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome."Hum. Mol. Genet. 6:1427-1434(1997) [PubMed] [Europe PMC] [Abstract]
  22. "Identification of a novel BLM missense mutation (2706T>C) in a Moroccan patient with Bloom's syndrome."Hum. Mutat. 15:584-585(2000) [PubMed] [Europe PMC] [Abstract]