Family With Sequence Similarity 20, Member C (FAM20C)

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DMP4; GEF-CK; Dentin Matrix Protein 4; Golgi-enriched fraction casein kinase; Extracellular serine/threonine protein kinase FAM20C

Family With Sequence Similarity 20, Member C (FAM20C)
DMP4 (FAM20C), from a rat odontoblast cDNA library. Using a partial rat DMP4 sequence, they obtained a full-length mouse Dmp4 cDNA, which encodes a deduced 579-amino acid protein with a 26-amino acid signal sequence, a Greek key calcium-binding domain, and a conserved C-terminal domain. The protein contains several potential N-linked glycosylation sites and has a calculated pI of 7.1, much different from other dentin matrix proteins, which are acidic. Northern blot analysis of mouse tissues showed highest levels of transcript in the dental pulp-odontoblast complex, moderate expression in bone, and low expression in kidney, liver, brain, and lung. Transfection experiments demonstrated perinuclear and cytoplasmic staining, consistent with an endoplasmic reticulum localization.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Family With Sequence Similarity 20, Member C (FAM20C)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Family With Sequence Similarity 20, Member C (FAM20C)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Family With Sequence Similarity 20, Member C (FAM20C)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Family With Sequence Similarity 20, Member C (FAM20C)CLIA Kit Customized Service Offer
n/aELISA Kit for Family With Sequence Similarity 20, Member C (FAM20C)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Family With Sequence Similarity 20, Member C (FAM20C)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Family With Sequence Similarity 20, Member C (FAM20C)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Family With Sequence Similarity 20, Member C (FAM20C)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Family With Sequence Similarity 20, Member C (FAM20C)CLIA Kit Customized Service Offer
n/aELISA Kit for Family With Sequence Similarity 20, Member C (FAM20C)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Family With Sequence Similarity 20, Member C (FAM20C)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Family With Sequence Similarity 20, Member C (FAM20C)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Family With Sequence Similarity 20, Member C (FAM20C)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Family With Sequence Similarity 20, Member C (FAM20C)CLIA Kit Customized Service Offer
n/aELISA Kit for Family With Sequence Similarity 20, Member C (FAM20C)ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells."BMC Genomics 6:11-11(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Secreted kinase phosphorylates extracellular proteins that regulate biomineralization."Science 336:1150-1153(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development."Am. J. Hum. Genet. 81:906-912(2007) [PubMed] [Europe PMC] [Abstract]