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La Ribonucleoprotein Domain Family, Member 7 (LARP7)

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HDCMA18P; PIP7S; P-TEFb-Interaction Protein For 7SK Stability; La Related Protein 7

La Ribonucleoprotein Domain Family, Member 7 (LARP7)
CCC K422
HGNC 24912
MGI 107634
PubMed 22865833
RGD 1586293
UniProt Q4G0J3
Nearly all nuclear 7SK was associated with PIP7S, and knockdown of PIP7S with short hairpin RNA (shRNA) reduced the levels of 7SK, indicating that PIP7S is required for 7SK stability. Moreover, knockdown of PIP7S with shRNA prevented formation of the 7SK snRNP and enhanced P-TEFb-dependent expression of a human immunodeficiency virus (HIV)-1 long terminal repeat(LTR)-driven reporter gene. Mutation analysis revealed that interaction of PIP7S with 7SK required the La and RRM motifs of PIP7S and the 3-prime UUU(OH) tail of 7SK, suggesting that PIP7S stabilizes 7SK against degradation by 3-prime exonucleases. Knockdown of PIP7S with shRNA in a normal human mammary epithelial cell line disrupted epithelial differentiation and cell morphology and caused P-TEFb-dependent malignant transformation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 7 (LARP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 7 (LARP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 7 (LARP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 7 (LARP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 7 (LARP7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 7 (LARP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 7 (LARP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 7 (LARP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 7 (LARP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 7 (LARP7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 7 (LARP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 7 (LARP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 7 (LARP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 7 (LARP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 7 (LARP7) ELISA Kit Customized Service Offer
  1. "The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes."EMBO Rep. 9:569-575(2008) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis."Mol. Cell 29:588-599(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Deep sequencing reveals 50 novel genes for recessive cognitive disorders." Nature 478:57-63(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism."Hum. Mutat. 33:1429-1434(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]