EGF Like Module Containing Mucin Like Hormone Receptor 3 (EMR3)

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EGF-like module receptor 3

EGF Like Module Containing Mucin Like Hormone Receptor 3 (EMR3)
EMR3 encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19.
This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.EMR3 contains an N-terminal signal peptide, 2 EGF-like domains, the first of which does not contain a calcium-binding sequence, a mucin-like spacer region with several N- and O-linked glycosylation sites, a putative GPCR proteolytic site, a TM7 region, and a 51-residue cytoplasmic tail. A truncated EMR3 splice variant containing only the 2 EGF-like domains and no transmembrane domain was predicted to be a soluble protein.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant EGF Like Module Containing Mucin Like Hormone Receptor 3 (EMR3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to EGF Like Module Containing Mucin Like Hormone Receptor 3 (EMR3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to EGF Like Module Containing Mucin Like Hormone Receptor 3 (EMR3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for EGF Like Module Containing Mucin Like Hormone Receptor 3 (EMR3)CLIA Kit Customized Service Offer
n/aELISA Kit for EGF Like Module Containing Mucin Like Hormone Receptor 3 (EMR3)ELISA Kit Customized Service Offer
  1. "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils."J. Biol. Chem. 276:18863-18870(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]