Programmed Cell Death Protein 2 (PDCD2)

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RP8; ZMYND7; Zinc finger protein Rp-8; Zinc finger MYND domain-containing protein 7

Programmed Cell Death Protein 2 (PDCD2)
PDCD2 encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Two transcripts encoding different proteins have been identified. PDCD2, contained an open reading frame of 1,032 bp encoding 344 amino acids; it showed 81% identity in DNA sequence and 83% identity in amino acid sequence to rat Rp8. The PDCD2 gene was expressed in all human tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Programmed Cell Death Protein 2 (PDCD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Programmed Cell Death Protein 2 (PDCD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Programmed Cell Death Protein 2 (PDCD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Programmed Cell Death Protein 2 (PDCD2)CLIA Kit Customized Service Offer
n/aELISA Kit for Programmed Cell Death Protein 2 (PDCD2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Programmed Cell Death Protein 2 (PDCD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Programmed Cell Death Protein 2 (PDCD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Programmed Cell Death Protein 2 (PDCD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Programmed Cell Death Protein 2 (PDCD2)CLIA Kit Customized Service Offer
n/aELISA Kit for Programmed Cell Death Protein 2 (PDCD2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Programmed Cell Death Protein 2 (PDCD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Programmed Cell Death Protein 2 (PDCD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Programmed Cell Death Protein 2 (PDCD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Programmed Cell Death Protein 2 (PDCD2)CLIA Kit Customized Service Offer
n/aELISA Kit for Programmed Cell Death Protein 2 (PDCD2)ELISA Kit Customized Service Offer
  1. "Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death."Cytogenet. Cell Genet. 71:41-43(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease."FEBS Lett. 583:521-525(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]