CDGSH Iron Sulfur Domain Protein 2 (CISD2)

[Edit]

ZCD2; WFS2; CDGSH2; Miner1; NAF-1; ERIS; Nutrient-deprivation autophagy factor-1; Wolfram Syndrome 2; Endoplasmic Reticulum Intermembrane Small Protein

CDGSH Iron Sulfur Domain Protein 2 (CISD2)
CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2 (WFS2).
The mutation disrupted the mRNA splicing by eliminating exon 2, and resulted in the introduction of a premature stop codon. Like wolframin, the CISD2-encoded protein, ERIS (endoplasmic reticulum intermembrane small protein), also localizes to the endoplasmic reticulum.Cisd2 gene is involved in mammalian life span control. In mice, Cisd2 was primarily localized to the mitochondria and associated with the outer mitochondrial membrane. Cisd2-null mice showed early senescence and shortened life span compared to wildtype mice.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant CDGSH Iron Sulfur Domain Protein 2 (CISD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to CDGSH Iron Sulfur Domain Protein 2 (CISD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to CDGSH Iron Sulfur Domain Protein 2 (CISD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for CDGSH Iron Sulfur Domain Protein 2 (CISD2)CLIA Kit Customized Service Offer
n/aELISA Kit for CDGSH Iron Sulfur Domain Protein 2 (CISD2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant CDGSH Iron Sulfur Domain Protein 2 (CISD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to CDGSH Iron Sulfur Domain Protein 2 (CISD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to CDGSH Iron Sulfur Domain Protein 2 (CISD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for CDGSH Iron Sulfur Domain Protein 2 (CISD2)CLIA Kit Customized Service Offer
n/aELISA Kit for CDGSH Iron Sulfur Domain Protein 2 (CISD2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant CDGSH Iron Sulfur Domain Protein 2 (CISD2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to CDGSH Iron Sulfur Domain Protein 2 (CISD2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to CDGSH Iron Sulfur Domain Protein 2 (CISD2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for CDGSH Iron Sulfur Domain Protein 2 (CISD2)CLIA Kit Customized Service Offer
n/aELISA Kit for CDGSH Iron Sulfur Domain Protein 2 (CISD2)ELISA Kit Customized Service Offer
  1. "A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2."Am. J. Hum. Genet. 81:673-683(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]