Snail Homolog 2 (SNAI2)

[Edit]

SLUG; SLUGH1; WS2D; Slug Homolog,Zinc Finger Protein; Neural crest transcription factor Slug

Snail Homolog 2 (SNAI2)
SNAI2 encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.
The deduced 268-amino acid protein has a calculated molecular mass of approximately 30 kD. It contains 5 zinc finger regions and shares 95% amino acid identity with mouse Slug. Northern blot analysis revealed a 2.2-kb SLUG transcript in placenta and adult heart, pancreas, liver, kidney, and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Snail Homolog 2 (SNAI2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Snail Homolog 2 (SNAI2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Snail Homolog 2 (SNAI2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Snail Homolog 2 (SNAI2)CLIA Kit Customized Service Offer
n/aELISA Kit for Snail Homolog 2 (SNAI2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Snail Homolog 2 (SNAI2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Snail Homolog 2 (SNAI2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Snail Homolog 2 (SNAI2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Snail Homolog 2 (SNAI2)CLIA Kit Customized Service Offer
n/aELISA Kit for Snail Homolog 2 (SNAI2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Snail Homolog 2 (SNAI2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Snail Homolog 2 (SNAI2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Snail Homolog 2 (SNAI2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Snail Homolog 2 (SNAI2)CLIA Kit Customized Service Offer
n/aELISA Kit for Snail Homolog 2 (SNAI2)ELISA Kit Customized Service Offer
  1. "Human Slug is a repressor that localizes to sites of active transcription."Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Human SLUG gene organization, expression, and chromosome map location on 8q."Genomics 51:468-471(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region."Mutat. Res. 406:63-69(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The SLUG zinc-finger protein represses E-cadherin in breast cancer."Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]
  7. "SLUG (SNAI2) deletions in patients with Waardenburg disease."Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Deletion of the SLUG (SNAI2) gene results in human piebaldism."Am. J. Med. Genet. A 122:125-132(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells."J. Biol. Chem. 280:17163-17171(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Slug gene expression supports human osteoblast maturation."Cell. Mol. Life Sci. 66:3641-3653(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors."J. Cell Sci. 122:1452-1460(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Slug contributes to the regulation of CXCL12 expression in human osteoblasts."Exp. Cell Res. 317:1159-1168(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Functional regulation of Slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation."FEBS J. 279:2929-2939(2012) [PubMed] [Europe PMC] [Abstract]