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Werner syndrome, RecQ Helicase Like (WRN)

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RECQL2; RECQL3; RECQ3; Werner syndrome ATP-dependent helicase; DNA helicase, RecQ-like type 3; Exonuclease WRN; RecQ protein-like 2

Werner syndrome, RecQ Helicase Like (WRN)
CCC L135
HGNC 12791
MGI 109635
PubMed 20934517
UniProt Q14191
Wiki WRN
WRN (Werner syndrome) is a human gene that provides instructions for producing Werner protein, which is a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA. These activities are necessary before DNA can be copied in preparation for cell division (DNA replication). Helicase enzymes are also critical for making a blueprint of a gene for protein production, a process called transcription. Further evidence suggests that Werner protein plays a critical role in repairing DNA. Overall, this protein helps maintain the structure and integrity of a person's DNA. The WRN gene is located on the short (p) arm of chromosome 8 between positions 12 and 11.2, from base pair 31,010,319 to base pair 31,150,818.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Werner syndrome, RecQ Helicase Like (WRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Werner syndrome, RecQ Helicase Like (WRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Werner syndrome, RecQ Helicase Like (WRN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Werner syndrome, RecQ Helicase Like (WRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Werner syndrome, RecQ Helicase Like (WRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Werner syndrome, RecQ Helicase Like (WRN) ELISA Kit Customized Service Offer
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  2. "Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer."Proc. Natl. Acad. Sci. U.S.A. 103:8822-8827(2006) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Nucleolar localization of the Werner syndrome protein in human cells."Proc. Natl. Acad. Sci. U.S.A. 95:6887-6892(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene."Genetics 151:1027-1039(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities."Biochemistry 41:2901-2912(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation."J. Biol. Chem. 277:18291-18302(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein."J. Biol. Chem. 278:23487-23496(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality."Mech. Ageing Dev. 128:609-617(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Werner syndrome protein interacts functionally with translesion DNA polymerases."Proc. Natl. Acad. Sci. U.S.A. 104:10394-10399(2007) [PubMed] [Europe PMC] [Abstract]
  11. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  12. "The Werner syndrome protein binds replication fork and Holliday junction DNAs as an oligomer."J. Biol. Chem. 283:24478-24483(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts."Cell Cycle 8:2769-2778(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation."PLoS ONE 4:E4825-E4825(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in gamma-irradiation-induced DNA damage responses."Biochemistry (Mosc.) 76:550-554(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein."Proc. Natl. Acad. Sci. U.S.A. 102:18379-18384(2005) [PubMed] [Europe PMC] [Abstract]
  23. "WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing."Nat. Struct. Mol. Biol. 13:414-422(2006) [PubMed] [Europe PMC] [Abstract]
  24. "WRN mutations in Werner syndrome."Hum. Mutat. 13:271-279(1999) [PubMed] [Europe PMC] [Abstract]
  25. "Solution structure of the helicase and RNase D C-terminal domain in Werner syndrome ATP-dependent helicase."Submitted (SEP-2006) to the PDB data bank
  26. "Crystal structure of the HRDC domain of human Werner syndrome protein, WRN."J. Biol. Chem. 282:2717-2728(2007) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN."Structure 18:177-187(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population."Am. J. Med. Genet. 68:494-498(1997) [PubMed] [Europe PMC] [Abstract]
  29. ErratumAm. J. Med. Genet. 70:103-103(1997)
  30. "Werner syndrome: characterization of mutations in the WRN gene in an affected family."Eur. J. Hum. Genet. 5:364-370(1997) [PubMed] [Europe PMC] [Abstract]
  31. "The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer."Hum. Mutat. 11:413-414(1998) [PubMed] [Europe PMC] [Abstract]
  32. "Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians."Am. J. Med. Genet. 82:399-403(1999) [PubMed] [Europe PMC] [Abstract]
  33. "The Werner syndrome gene and global sequence variation."Genomics 71:118-122(2001) [PubMed] [Europe PMC] [Abstract]
  34. "The spectrum of WRN mutations in Werner syndrome patients." Hum. Mutat. 27:558-567(2006) [PubMed] [Europe PMC] [Abstract]
  35. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  36. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]