Werner syndrome, RecQ Helicase Like (WRN)

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RECQL2; RECQL3; RECQ3; Werner syndrome ATP-dependent helicase; DNA helicase, RecQ-like type 3; Exonuclease WRN; RecQ protein-like 2

Werner syndrome, RecQ Helicase Like (WRN)
WRN (Werner syndrome) is a human gene that provides instructions for producing Werner protein, which is a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA. These activities are necessary before DNA can be copied in preparation for cell division (DNA replication). Helicase enzymes are also critical for making a blueprint of a gene for protein production, a process called transcription. Further evidence suggests that Werner protein plays a critical role in repairing DNA. Overall, this protein helps maintain the structure and integrity of a person's DNA. The WRN gene is located on the short (p) arm of chromosome 8 between positions 12 and 11.2, from base pair 31,010,319 to base pair 31,150,818.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Werner syndrome, RecQ Helicase Like (WRN)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Werner syndrome, RecQ Helicase Like (WRN)CLIA Kit Customized Service Offer
n/aELISA Kit for Werner syndrome, RecQ Helicase Like (WRN)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Werner syndrome, RecQ Helicase Like (WRN)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Werner syndrome, RecQ Helicase Like (WRN)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Werner syndrome, RecQ Helicase Like (WRN)CLIA Kit Customized Service Offer
n/aELISA Kit for Werner syndrome, RecQ Helicase Like (WRN)ELISA Kit Customized Service Offer
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  10. "Werner syndrome protein interacts functionally with translesion DNA polymerases."Proc. Natl. Acad. Sci. U.S.A. 104:10394-10399(2007) [PubMed] [Europe PMC] [Abstract]
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  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts."Cell Cycle 8:2769-2778(2009) [PubMed] [Europe PMC] [Abstract]
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  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein."Proc. Natl. Acad. Sci. U.S.A. 102:18379-18384(2005) [PubMed] [Europe PMC] [Abstract]
  23. "WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing."Nat. Struct. Mol. Biol. 13:414-422(2006) [PubMed] [Europe PMC] [Abstract]
  24. "WRN mutations in Werner syndrome."Hum. Mutat. 13:271-279(1999) [PubMed] [Europe PMC] [Abstract]
  25. "Solution structure of the helicase and RNase D C-terminal domain in Werner syndrome ATP-dependent helicase."Submitted (SEP-2006) to the PDB data bank
  26. "Crystal structure of the HRDC domain of human Werner syndrome protein, WRN."J. Biol. Chem. 282:2717-2728(2007) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN."Structure 18:177-187(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population."Am. J. Med. Genet. 68:494-498(1997) [PubMed] [Europe PMC] [Abstract]
  29. ErratumAm. J. Med. Genet. 70:103-103(1997)
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  32. "Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians."Am. J. Med. Genet. 82:399-403(1999) [PubMed] [Europe PMC] [Abstract]
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  35. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
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