Notch Homolog 4 (NOTCH4)

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INT3; Neurogenic locus notch homolog protein 4

Notch Homolog 4 (NOTCH4)
NOTCH4 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL149Hu01 Recombinant Notch Homolog 4 (NOTCH4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL149Hu01 Polyclonal Antibody to Notch Homolog 4 (NOTCH4) WB; IHC; ICC; IP.
Assay Kits SEL149Hu ELISA Kit for Notch Homolog 4 (NOTCH4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Notch Homolog 4 (NOTCH4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Notch Homolog 4 (NOTCH4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Notch Homolog 4 (NOTCH4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Notch Homolog 4 (NOTCH4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Notch Homolog 4 (NOTCH4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL149Ra01 Recombinant Notch Homolog 4 (NOTCH4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL149Ra01 Polyclonal Antibody to Notch Homolog 4 (NOTCH4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Notch Homolog 4 (NOTCH4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Notch Homolog 4 (NOTCH4) ELISA Kit Customized Service Offer
  1. "Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3."Gene 189:235-244(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene."Genomics 51:45-58(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Human ligands of the Notch receptor."Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
  5. "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."Nat. Genet. 26:484-489(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."Mol. Cell. Biol. 22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]