Cytochrome P450 4V2 (CYP4V2)

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BCD; CYP4AH1; Cytochrome P450 Family 4 Subfamily V Polypeptide 2; Docosahexaenoic acid omega-hydroxylase CYP4V2

Cytochrome P450 4V2 (CYP4V2)
The CYP4V2 gene contains 11 exons spanning 19 kb. The coding sequence begins in exon 1 and continues through exon 11.The predicted transmembrane segment of CYP4V2 resides near the N terminus, followed by a globular structural domain typical of the CYP450 family. The globular domain of CYP4V2 comprises 18 helices and beta structural segments.
PCR of human tissue-specific cDNA showed expression of CYP4V2 in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium, and lymphocytes. Highest expression was found in retina. The expression of CYP4V2 in a wide variety of tissues is consistent with inclusions and their clinical sequelae found in the cornea, retina, and lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cytochrome P450 4V2 (CYP4V2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cytochrome P450 4V2 (CYP4V2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cytochrome P450 4V2 (CYP4V2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cytochrome P450 4V2 (CYP4V2)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome P450 4V2 (CYP4V2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cytochrome P450 4V2 (CYP4V2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cytochrome P450 4V2 (CYP4V2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cytochrome P450 4V2 (CYP4V2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cytochrome P450 4V2 (CYP4V2)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome P450 4V2 (CYP4V2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cytochrome P450 4V2 (CYP4V2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cytochrome P450 4V2 (CYP4V2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cytochrome P450 4V2 (CYP4V2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cytochrome P450 4V2 (CYP4V2)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome P450 4V2 (CYP4V2)ELISA Kit Customized Service Offer
  1. "Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2."Am. J. Hum. Genet. 74:817-826(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase."Drug Metab. Dispos. 37:2119-2122(2009) [PubMed] [Europe PMC] [Abstract]
  6. "CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant."Mol. Pharmacol. 82:679-686(2012) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]