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Eukaryotic Translation Initiation Factor 5A2 (EIF5A2)

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EIF-5A2; eIF5AII; Eukaryotic initiation factor 5A isoform 2

Eukaryotic Translation Initiation Factor 5A2 (EIF5A2)
CCC L486
HGNC 3301
MGI 1933735
PubMed 21813470
RGD 1306196
UniProt Q9GZV4
Wiki EIF5A2
Antisense DNA against EIF5A2 could inhibit cell growth in an ovarian cancer cell line in which EIF5A2 was amplified in the form of double minute chromosomes. Cell growth in this cell line was also inhibited when expression of EIF5A2 was decreased by reduction of the copy number of double minute chromosomes. Microarray analysis showed that EIF5A2 overexpression was significantly associated with advanced stages of ovarian cancer.
The predicted 153-amino acid protein is 84% identical and 94% similar to EIF5A. RNA array analysis revealed strongest expression in testis and adult brain; expression was not found in fetal brain. Strong expression was also detected in a colorectal tumor cell line, although only low levels were detected in normal intestinal tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Polyclonal Antibody Customized Service Offer
Assay Kits SEL486Hu ELISA Kit for Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) ELISA Kit Customized Service Offer
  1. "Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer."Cancer Res. 61:3806-3809(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression."Genomics 71:101-109(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of eukaryotic initiation factor 5A-2."Eur. J. Biochem. 270:4254-4263(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells."FEBS J. 273:1102-1114(2006) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Screening the SPO11 and EIF5A2 genes in a population of infertile men."Fertil. Steril. 84:758-760(2005) [PubMed] [Europe PMC] [Abstract]