Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)

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4.1B; DAL-1; DAL1; Differentially expressed in adenocarcinoma of the lung protein 1

Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)
DAL1 is 73% identical in its N-terminal domain to members of the protein 4.1 family and shares structural similarity to the Drosophila 4.1 homolog 'coracle.' DAL1 is normally expressed at high levels in brain, with lower levels in kidney, intestine, and testis. DAL1 loss in 60% of sporadic meningiomas. Analogous to merlin, the authors showed that DAL1 loss is an early event in meningioma tumorigenesis, suggesting that these 2 protein-4.1 family members are critical growth regulators in the pathogenesis of meningiomas. The authors hypothesized that membrane-associated alterations may be important in the early stages of neoplastic transformation. EPB41 and EPB41L3 genes from fish, bird, amphibian, and mammalian genomes exhibit shared features, including alternative first exons and differential splicing acceptors in exon 2.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)CLIA Kit Customized Service Offer
n/aELISA Kit for Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)CLIA Kit Customized Service Offer
n/aELISA Kit for Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)CLIA Kit Customized Service Offer
n/aELISA Kit for Erythrocyte Membrane Protein Band 4.1 Like Protein 3 (EPB41L3)ELISA Kit Customized Service Offer
  1. "A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer."Cancer Res. 59:35-43(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer."Cancer Res. 62:5129-5133(2002) [PubMed] [Europe PMC] [Abstract]
  7. "DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo."Oncogene 23:7761-7771(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The tumor suppressor DAL-1/4.1B modulates protein arginine N-methyltransferase 5 activity in a substrate-specific manner."Biochem. Biophys. Res. Commun. 329:522-530(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells."Mol. Cancer 5:4-4(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B)."J. Biol. Chem. 286:4511-4516(2011) [PubMed] [Europe PMC] [Abstract]