Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)

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HFTC; HHS; GalNAc-T3; Polypeptide GalNAc transferase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3

Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)
GALNT3 encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities.
Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)CLIA Kit Customized Service Offer
n/aELISA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)CLIA Kit Customized Service Offer
n/aELISA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)CLIA Kit Customized Service Offer
n/aELISA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 3 (GALNT3)ELISA Kit Customized Service Offer
  1. "cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase, GalNAc-T3."J. Biol. Chem. 271:17006-17012(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3."J. Biol. Chem. 272:23503-23514(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus."J. Cell Sci. 111:45-60(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma."Cancer Sci. 94:32-36(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis."Nat. Genet. 36:579-581(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders."J. Mol. Med. 83:33-38(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation."J. Biol. Chem. 281:18370-18377(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]