GATA Binding Protein 6 (GATA6)

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Transcription factor GATA-6

GATA Binding Protein 6 (GATA6)
The cDNA encodes a predicted 449-amino acid protein that is highly conserved among vertebrates and includes 2 adjacent zinc finger/basic domains characteristic of the GATA factor family. The gene is transcribed in a pattern overlapping that of GATA4. Transcripts for both of these genes are prominent in heart, pancreas, and ovary, but only GATA6 mRNA was found in lung and liver.
GATA6 transcripts were also detected in cultures of human and rat vascular smooth muscle cells. In these cells, GATA6 transcripts were downregulated when quiescent cultures were stimulated to proliferate in response to mitogen activation. The results demonstrate that GATA6 is subject to both tissue-specific and mitogen-responsive regulatory signals.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GATA Binding Protein 6 (GATA6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GATA Binding Protein 6 (GATA6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GATA Binding Protein 6 (GATA6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GATA Binding Protein 6 (GATA6)CLIA Kit Customized Service Offer
n/aELISA Kit for GATA Binding Protein 6 (GATA6)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GATA Binding Protein 6 (GATA6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GATA Binding Protein 6 (GATA6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GATA Binding Protein 6 (GATA6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GATA Binding Protein 6 (GATA6)CLIA Kit Customized Service Offer
n/aELISA Kit for GATA Binding Protein 6 (GATA6)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GATA Binding Protein 6 (GATA6)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GATA Binding Protein 6 (GATA6)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GATA Binding Protein 6 (GATA6)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GATA Binding Protein 6 (GATA6)CLIA Kit Customized Service Offer
n/aELISA Kit for GATA Binding Protein 6 (GATA6)ELISA Kit Customized Service Offer
  1. "The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals."Genomics 38:283-290(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut."Biochim. Biophys. Acta 1353:98-102(1997) [PubMed] [Europe PMC] [Abstract]
  3. "GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells."FEBS Lett. 414:333-337(1997) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The human and mouse GATA-6 genes utilize two promoters and two initiation codons."J. Biol. Chem. 274:38004-38016(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling."Proc. Natl. Acad. Sci. U.S.A. 106:13933-13938(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect."J. Hum. Genet. 55:662-667(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of GATA6 sequence variants in patients with congenital heart defects."Pediatr. Res. 68:281-285(2010) [PubMed] [Europe PMC] [Abstract]
  12. "GATA6 haploinsufficiency causes pancreatic agenesis in humans."Nat. Genet. 44:20-22(2012) [PubMed] [Europe PMC] [Abstract]